Publication Name	World Journal of Stem Cells
Manuscript ID	113694
Country	China

Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Alpha-ketoglutarate enhances adipose-derived stem cells survival in wound healing by hypoxia-inducible factor 1-alpha-mediated redox homeostasis and glycogen-dependent bioenergetics
Manuscript Source	Unsolicited Manuscript
All Author List	Daniyaer Dilimulati, Diyaer Dilimulati and Lei Cui
Funding Agency and Grant Number
Corresponding Author	Lei Cui, /, Shanghai Tenth People’s Hospital, No. 1239 Siping Road, Shanghai 200072, China. 14209@tongji.edu.cn
Key Words	Adipose-derived stem cells; Alpha-ketoglutarate; Hypoxia-inducible factor 1-alpha; Redox homeostasis; Glycogen metabolism; Wound healing; Oxidative stress
Core Tip	This study reveals that preconditioning adipose-derived stem cells with α-ketoglutarate enhances their survival in burn wounds through hypoxia-inducible factor 1α-mediated dual metabolic adaptations. Hypoxia-inducible factor 1α activation simultaneously promotes glutamine metabolism for antioxidant glutathione synthesis and enhances glycogen storage for energy maintenance under stress. This metabolic reprogramming strategy significantly improves cell viability and wound healing efficacy, offering a novel approach to enhance stem cell-based therapies in regenerative medicine.
Citation	Dilimulati D, Dilimulati D, Cui L. Alpha-ketoglutarate enhances adipose-derived stem cells survival in wound healing by hypoxia-inducible factor 1-alpha-mediated redox homeostasis and glycogen-dependent bioenergetics. World J Stem Cells 2025; In press

Received	2025-09-02 06:31
Peer-Review Started	2025-09-02 06:32
First Decision by Editorial Office Director	2025-09-30 08:00
Return for Revision	2025-09-30 08:00
Revised	2025-10-13 11:06
Publication Fee Transferred	2025-10-17 13:44
Second Decision by Editor	2025-12-15 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-22 09:43
Articles in Press	2025-12-22 09:43
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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