Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	113699
Country	Pakistan

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Diagnostic accuracy and safety of endoscopic ultrasound-guided fine needle biopsy for evaluating mediastinal pathologies
Manuscript Source	Invited Manuscript
All Author List	Masood Muhammad Karim, Syedda Ayesha, Abdul Hadi Shahid, Muhammad Salman, Danaish Kumar, Zeeshan Uddin and Adeel Ur Rehman
Funding Agency and Grant Number
Corresponding Author	Adeel Ur Rehman, Assistant Professor, Section of Gastroenterology, Department of Medicine, Aga Khan University, Karachi 74800, Sindh, Pakistan. rehman.adeel@aku.edu
Key Words	Mediastinal mass; Mediastinal lymphadenopathy; Mediastinal lesion; Endoscopic ultrasound-guided fine needle biopsy; Malignancy; Diagnostic yield; Minimally invasive diagnosis and low- and middle-income countries
Core Tip	Endoscopic ultrasound-guided fine-needle biopsy (EUS-FNB) is a minimally invasive technique that enables accurate tissue sampling of mediastinal lesions. In this single-centre study from Pakistan, EUS-FNB demonstrated excellent diagnostic performance, with 94.8% diagnostic yield, 88.9% sensitivity, and 100% specificity, while maintaining a strong safety profile without procedure-related complications. The study highlights the value of EUS-FNB in guiding management of both benign and malignant mediastinal pathologies and addressing a critical evidence gap in low- and middle-income country settings, where data remain limited.
Citation	Karim MM, Ayesha S, Shahid AH, Salman M, Kumar D, Uddin Z, Rehman AU. Diagnostic accuracy and safety of endoscopic ultrasound-guided fine needle biopsy for evaluating mediastinal pathologies. World J Gastrointest Endosc 2025; In press

Received	2025-09-02 05:49
Peer-Review Started	2025-09-02 05:49
First Decision by Editorial Office Director	2025-09-18 09:32
Return for Revision	2025-09-18 09:32
Revised	2025-10-02 08:13
Publication Fee Transferred
Second Decision by Editor	2025-12-17 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-17 07:06
Articles in Press	2025-12-17 07:06
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5190 (online)
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