Publication Name	World Journal of Psychiatry
Manuscript ID	113723
Country	China

Category	Psychiatry
Manuscript Type	Case Report
Article Title	Hypertension induced by sudden clozapine withdrawal in a schizophrenia patient with metabolic syndrome: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Ji-Zhou Liu, Ting Ma, Zi-Yan Liang, Xuan-Bo Ning, Wang-Jin Li, Jian-Ping Wang, Yan-Li Jin, Ning Zhou and Jin-Feng Li
Funding Agency and Grant Number
Corresponding Author	Jin-Feng Li, Department of Psychiatry, Hospital for Infectious Diseases, Dongfanghong Farm, Yuguopu Subdistrict, Mengzi 661002, Honghe Hani and Yi Autonomous Prefecture, China. 17145353@qq.com
Key Words	Schizophrenia; Metabolic syndrome; Clozapine withdrawal; Hypertension; Case report
Core Tip	This case is the first to describe severe, refractory hypertension as a consequence of sudden clozapine withdrawal in a patient with treatment-resistant schizophrenia and metabolic syndrome. Blood pressure remained uncontrolled despite intensive antihypertensive therapy, while normalized rapidly after clozapine reintroduction. These findings demonstrate that hypertension may be an unrecognized manifestation of clozapine withdrawal and highlight the critical importance of vigilant blood pressure monitoring, gradual tapering, and, when necessary, reintroduction of clozapine. This report contributes to the understanding of clozapine withdrawal syndromes and provides valuable clinical guidance for the safe management of affected patients.
Citation	Liu JZ, Ma T, Liang ZY, Ning XB, Li WJ, Wang JP, Jin YL, Zhou N, Li JF. Hypertension induced by sudden clozapine withdrawal in a schizophrenia patient with metabolic syndrome: A case report. World J Psychiatry 2026; In press

Received	2025-09-02 06:12
Peer-Review Started	2025-09-02 06:12
First Decision by Editorial Office Director	2025-11-06 08:27
Return for Revision	2025-11-06 08:27
Revised	2025-12-16 13:48
Publication Fee Transferred	2025-12-29 10:17
Second Decision by Editor	2026-02-09 02:47
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-09 06:27
Articles in Press	2026-02-09 06:27
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Typeset the Manuscript

ISSN	2220-3206 (online)
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