Publication Name	World Journal of Diabetes
Manuscript ID	113748
Country	Italy

Category	Medicine, General & Internal
Manuscript Type	Review
Article Title	Serum biomarkers in diabetic kidney disease: A comprehensive narrative review
Manuscript Source	Invited Manuscript
All Author List	Guido Gembillo, Luca Soraci, Giuseppe Spadaro, Rossella Messina, Felicia Cuzzola, Michela Calderone, Maria F Ricca, Simona Di Piazza, Flavia Sudano, Maria E Gambuzza, Maria Princiotto, Lorenzo Lo Cicero and Domenico Santoro
Funding Agency and Grant Number
Corresponding Author	Guido Gembillo, Unit of Nephrology and Dialysis, Department of Clinical and Experimental Medicine, University of Messina, Via Consolare Valeria, 1, Messina 98125, Sicilia, Italy. guidogembillo@live.it
Key Words	Diabetic nephropathy; Chronic kidney disease; Albuminuria; Renal function; Inflammation markers; Diabetes; Biomarkers
Core Tip	Diabetic kidney disease is the main cause of end-stage renal disease, yet early detection is limited by the poor sensitivity of serum creatinine and estimated glomerular filtration rate. Novel biomarkers such as cystatin C, neutrophil gelatinase-associated lipocalin, kidney injury molecule-1, and tumor necrosis factor receptors show superior accuracy for identifying early damage and predicting progression. Emerging markers, including adropin, soluble urokinase plasminogen activator receptor, monocyte chemoattractant protein-1, chitinase-3-like protein 1, endostatin, zinc-α2-glycoprotein, PromarkerD, and microRNAs, provide additional value for risk stratification and personalized therapy. Integration of validated multi-marker panels may transform monitoring and management, improving outcomes for patients with diabetes.
Citation	Gembillo G, Soraci L, Spadaro G, Messina R, Cuzzola F, Calderone M, Ricca MF, Di Piazza S, Sudano F, Gambuzza ME, Princiotto M, Lo Cicero L, Santoro D. Serum biomarkers in diabetic kidney disease: A comprehensive narrative review. World J Diabetes 2026; In press

Received	2025-09-02 04:54
Peer-Review Started	2025-09-05 00:07
First Decision by Editorial Office Director	2025-10-17 07:10
Return for Revision	2025-10-17 07:10
Revised	2025-12-05 18:01
Publication Fee Transferred
Second Decision by Editor	2026-02-06 02:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-06 04:31
Articles in Press	2026-02-06 04:31
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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