Publication Name	World Journal of Gastroenterology
Manuscript ID	113771
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Pristimerin ameliorates spasmolytic polypeptide-expressing metaplasia by modulating Cdkn1c (p57)-mediated glycolytic reprogramming
Manuscript Source	Unsolicited Manuscript
All Author List	Jun-Song Wen, Zi-Wei Pan, Xue-Dan Yao, Yan-Qing Liu and Yao-Dong Zhu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82274355 Key Project for the Cultivation of Outstanding Young Teachers in Anhui Province’s Colleges and Universities No. 2023-385
Corresponding Author	Yao-Dong Zhu, Chief Physician, Doctorate Student, Professor, Department of Integrated Traditional Chinese and Western Medicine Oncology, First Affiliated Hospital of Anhui Medical University, No. 120 Wanshui Road, High-tech Zone, Hefei 230000, Anhui Province, China. zhuyaodong2022@126.com
Key Words	Pristimerin; Spasmolytic polypeptide-expressing metaplasia; Glycolytic reprogramming; Cdkn1c; Gastric organoids; Gastric precancerous lesion
Core Tip	This study systematically investigated the therapeutic effects of the natural compound pristimerin on spasmolytic polypeptide-expressing metaplasia (SPEM) using a high-dose tamoxifen-induced mouse model, tamoxifen-treated human gastric epithelial cells, and N-methyl-N’-nitro-N-nitrosoguanidine/Helicobacter pylori-induced gastric organoids. It elucidated the underlying mechanism by which pristimerin ameliorates SPEM through regulating Cdkn1c (p57) to suppress glycolytic reprogramming. These findings not only provide novel mechanistic insights into pristimerin treatment for SPEM but also offer a crucial theoretical basis for targeting p57 in SPEM therapy.
Citation	Wen JS, Pan ZW, Yao XD, Liu YQ, Zhu YD. Pristimerin ameliorates spasmolytic polypeptide-expressing metaplasia by modulating Cdkn1c (p57)-mediated glycolytic reprogramming. World J Gastroenterol 2025; In press

Received	2025-09-10 07:14
Peer-Review Started	2025-09-10 07:16
First Decision by Editorial Office Director	2025-10-18 02:38
Return for Revision	2025-10-18 02:38
Revised	2025-10-31 12:01
Publication Fee Transferred	2025-11-10 03:59
Second Decision by Editor	2025-12-16 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-16 07:10
Articles in Press	2025-12-16 07:10
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Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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