Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	113781
Country	China

Category	Oncology
Manuscript Type	Basic Study
Article Title	MiR-27b-5p promotes gastric cancer progression by targeting CREBZF to regulate the STAT3 pathway
Manuscript Source	Unsolicited Manuscript
All Author List	Fu-Chao Ma, Guan-Lan Zhang, Guo-Qiang Chen, Jing-Wen Ling, Yu-Feng Li, Bang-Teng Chi, Yu-Lu Tang, Wei Peng, Gang Chen, Dan-Ming Wei, Min-Hua Rong and Lian-Ying Ge
Funding Agency and Grant Number	Funding Agency Grant Number Guangxi Zhuang Autonomous Region Health Commission Scientific Research Project Z-A20220465 Guangxi Key Research and Development Plan AB20297021 Guangxi Medical and Health Appropriate Technology Development and Promotion Application Project S2022107 China Undergraduate Innovation and Entrepreneurship Training Program S202310598074 Future Academic Star of Guangxi Medical University WLXSZX23109
Corresponding Author	Lian-Ying Ge, Department of Endoscopy, Guangxi Medical University Cancer Hospital, No. 71 Hedi Road, Nanning 530021, Guangxi Zhuang Autonomous Region, China. gxgly@hotmail.com
Key Words	Gastric cancer; MiR-27b-5p; cAMP response element-binding protein zinc finger; Signal transducer and activator of transcription 3 pathway; MicroRNAs
Core Tip	Our findings provide preliminary evidence that reduction of miR-27b-5p restrains proliferation and migration of gastric cancer cells. Our investigation also indicates that elevated expression level of miR-27b-5p suppresses gene expression related to the signal transducer and activator of transcription 3 signaling pathway, mainly targeting cAMP response element-binding protein zinc finger. Specifically, this regulatory process includes upregulation of signal transducer and activator of transcription 3, cellular myelocytomatosis oncogene, cyclin D1, B-cell lymphoma 2, and survivin, as well as the downregulation of Bcl-2-associated X protein, Bcl-2-associated X protein/B-cell lymphoma 2 ratio, and cAMP response element-binding protein zinc finger. These molecular mechanisms enhance the proliferation of gastric cancer cells.
Citation	Ma FC, Zhang GL, Chen GQ, Ling JW, Li YF, Chi BT, Tang YL, Peng W, Chen G, Wei DM, Rong MH, Ge LY. MiR-27b-5p promotes gastric cancer progression by targeting CREBZF to regulate the STAT3 pathway. World J Gastrointest Oncol 2025; In press

Received	2025-09-03 09:07
Peer-Review Started	2025-09-03 09:07
First Decision by Editorial Office Director	2025-10-11 06:57
Return for Revision	2025-10-12 06:13
Revised	2025-11-01 15:39
Publication Fee Transferred	2025-11-05 14:03
Second Decision by Editor	2025-12-23 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-23 09:19
Articles in Press	2025-12-23 09:19
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com