Publication Name	World Journal of Orthopedics
Manuscript ID	113798
Country	China

Category	Orthopedics
Manuscript Type	Minireviews
Article Title	Advances in bone tissue engineering and three-dimensional printing: Current strategies and future perspectives in orthopaedics
Manuscript Source	Invited Manuscript
All Author List	Yu-Hua Ruan, Peng Wang, Xiao-Dong Tang, Qi Zhang, Peng Yan, Yi-Gong Tian, Cheng-Jin Li, Wei-Ping Fu, Rui-Bo Wang and Chang-Jiang Zhang
Funding Agency and Grant Number	Funding Agency Grant Number Henan Province Key Research and Development Program 231111311000 Henan Provincial Science and Technology Research Project 232102310411 Henan Province Medical Science and Technology Key Project LHGJ20220566, LHGJ20240365 Henan Province Medical Education Research Project WJLX2023079 Zhengzhou Medical and Health Technology Innovation Guidance Program 2024YLZDJH022
Corresponding Author	Chang-Jiang Zhang, Second Department of Orthopedics, The Fifth Affiliated Hospital of Zhengzhou University, No. 3 Kangfu Qianjie, Erqi District, Zhengzhou 450052, Henan Province, China. changjiangzhang1968@outlook.com
Key Words	Bone tissue engineering; Scaffold materials; Stem cells; Bone regeneration; Bioprinting; Orthopaedic applications; Clinical translation
Core Tip	The combination of bone tissue engineering and three-dimensional printing presents a powerful strategy for tailored repair of bone defects. By integrating biocompatible scaffolds, stem cells, and bioactive molecules with precise three-dimensional fabrication, it is possible to create constructs that closely replicate native bone structure and support effective regeneration. Recent advances in smart biomaterials and bioprinting techniques have further improved scaffold functionality and therapeutic outcomes. However, challenges, including vascularization, controlled scaffold degradation, and clinical translation, remain to be fully addressed. Ongoing interdisciplinary efforts will be crucial in overcoming these hurdles and advancing these promising technologies into routine orthopaedic care.
Citation	Ruan YH, Wang P, Tang XD, Zhang Q, Yan P, Tian YG, Li CJ, Fu WP, Wang RB, Zhang CJ. Advances in bone tissue engineering and three-dimensional printing: Current strategies and future perspectives in orthopaedics. World J Orthop 2025; In press

Received	2025-09-04 03:29
Peer-Review Started	2025-09-04 03:29
First Decision by Editorial Office Director	2025-09-30 08:34
Return for Revision	2025-09-30 08:34
Revised	2025-10-11 05:04
Publication Fee Transferred
Second Decision by Editor	2025-12-22 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-23 00:28
Articles in Press	2025-12-23 00:28
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-5836 (online)
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