Publication Name	World Journal of Gastroenterology
Manuscript ID	113810
Country	France

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Multibipolar radiofrequency vs single needle microwave ablation for the treatment of newly diagnosed hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Cécilia Bahloul, Agnès Rode, Pierre Pradat, Laurent Milot, Jérôme Dumortier, Philippe Merle, Jean-Yves Mabrut, Loïc Boussel and Angelo Della Corte
Funding Agency and Grant Number
Corresponding Author	Angelo Della Corte, Department of Radiology, Hospices Civils de Lyon, 103 Gd Rue de la Croix-Rousse, Lyon 69002, Auvergne-Rhône-Alpes, France. a.dellacortetartaglione@gmail.com
Key Words	Local tumor progression; Ablation; Microwave; Radiofrequency; Hepatocellular carcinoma
Core Tip	There is limited data comparing multibipolar radiofrequency ablation (mbp-RFA) and microwave ablation (MWA) for treating hepatocellular carcinoma (HCC). This study analyzed 362 patients with newly diagnosed HCC who underwent either mbp-RFA (242 patients, 323 tumors) or MWA (120 patients, 168 tumors). Results showed that mbp-RFA provided better local tumor control, with a lower local tumor progression rate (11.4% vs 25.2%) and a higher complete ablation rate (94.1% vs 87.5%) compared to MWA. The advantage of mbp-RFA was particularly significant for tumors larger than 3 cm, where MWA had a local tumor progression rate of 60.9% vs 21.6% with mbp-RFA. Despite these differences in efficacy, both techniques had similar major complication rates (9.5% vs 7.5%). These findings suggest that mbp-RFA is a more effective option for larger, treatment-naïve HCC tumors while maintaining a comparable safety profile.
Citation	Bahloul C, Rode A, Pradat P, Milot L, Dumortier J, Merle P, Mabrut JY, Boussel L, Della Corte A. Multibipolar radiofrequency vs single needle microwave ablation for the treatment of newly diagnosed hepatocellular carcinoma. World J Gastroenterol 2025; In press

Received	2025-09-04 06:26
Peer-Review Started	2025-09-04 06:26
To Make the First Decision
Return for Revision	2025-09-17 09:29
Revised	2025-10-01 07:00
Second Decision	2025-11-24 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-24 09:11
Articles in Press	2025-11-24 09:11
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com