Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	113816
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Meta-Analysis
Article Title	Efficacy of regorafenib in the treatment of advanced hepatocellular carcinoma: A systematic review and meta-analysis
Manuscript Source	Unsolicited Manuscript
All Author List	Zhang Cheng and Ai-Min Yue
Funding Agency and Grant Number
Corresponding Author	Ai-Min Yue, MD, Department of Surgical Oncology, Xinxiang Central Hospital, The Fourth Clinical College of Xinxiang Medical University, No. 56 Jinsui Avenue, Xinxiang 453000, Henan Province, China. yueaimin2025@163.com
Key Words	Regorafenib; Hepatocellular carcinoma; Second-line therapy; Overall survival; Meta-analysis
Core Tip	This study presents a comprehensive synthesis of current evidence regarding regorafenib’s clinical performance as a second-line treatment in patients with advanced hepatocellular carcinoma. Utilizing data from nine eligible studies, our meta-analysis provides an updated assessment of survival outcomes and tumor response metrics. Notably, regorafenib demonstrated a statistically significant improvement in overall survival compared to control groups, while objective tumor response rates did not show superiority, particularly when compared to immunotherapies such as nivolumab. Our results highlight regorafenib’s survival benefit and its role within a competitive therapeutic landscape.
Citation	Cheng Z, Yue AM. Efficacy of regorafenib in the treatment of advanced hepatocellular carcinoma: A systematic review and meta-analysis. World J Gastrointest Oncol 2025; In press

Received	2025-09-04 03:28
Peer-Review Started	2025-09-04 03:28
To Make the First Decision
Return for Revision	2025-09-29 09:28
Revised	2025-10-12 04:19
Second Decision	2025-11-24 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-24 07:30
Articles in Press	2025-11-24 07:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
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