Publication Name	World Journal of Diabetes
Manuscript ID	113843
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Circulating microbiome and its clinical implications in diabetes mellitus: Mechanistic insights and therapeutic perspectives
Manuscript Source	Invited Manuscript
All Author List	Dinakaran Vasudevan
Funding Agency and Grant Number
Corresponding Author	Dinakaran Vasudevan, PhD, Senior Scientist, Gut Microbiome Division, Scientific Knowledge on Aging and Neurological Ailments (SKAN) Research Trust, Happiest Health Office, No.141/2, Gate 4, St. John’s Research Institute, 100 Feet Road, KHB Block, John Nagar, Koramangala, Bangalore 560034, Karnataka, India. dinakaran.svgev@gmail.com
Key Words	Circulating microbiome; Blood microbiome; Microbial components; Toll-like receptors; Trimethylamine N-oxide; Short chain fatty acids
Core Tip	The circulating microbiome encompassing microbial DNA, products, and viable microbes detected in blood, links gut barrier dysfunction to chronic, low-grade inflammation in diabetes. Quantifying blood microbial signatures (16S rDNA/cell free DNA, endotoxin activity, metabolites) may enable early risk stratification for insulin resistance and prediction of micro- and macrovascular complications. Integrating longitudinal cell free microbiome profiling with glycaemic and inflammatory indices could refine diagnosis, personalize therapy, and monitor responses to interventions (dietary fiber, pre/probiotics, postbiotics, barrier-restoring strategies, and microbiome-informed pharmacotherapy such as metformin). Standardized sampling, contamination control, and causal studies are critical to translate these insights into routine diabetes care.
Citation	Vasudevan D. Circulating microbiome and its clinical implications in diabetes mellitus: Mechanistic insights and therapeutic perspectives. World J Diabetes 2026; In press

Received	2025-09-05 01:40
Peer-Review Started	2025-09-05 07:32
First Decision by Editorial Office Director	2025-10-17 07:20
Return for Revision	2025-10-17 07:20
Revised	2025-12-02 15:29
Publication Fee Transferred
Second Decision by Editor	2026-01-14 02:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-14 08:56
Articles in Press	2026-01-14 08:56
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com