Publication Name	World Journal of Gastroenterology
Manuscript ID	113845
Country	Brazil

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Gallbladder carcinoma in Brazil: Clinicopathological profile and survival outcomes from a high-volume cancer center
Manuscript Source	Invited Manuscript
All Author List	Fabio Ferrari Makdissi, Lucas Eiki Kawakami, Marina Alessandra Pereira, Jaime Arthur Pirola Kruguer, Gilton Fonseca Marques, Fabricio Ferreira Coelho, José Jukemura and Paulo Herman
Funding Agency and Grant Number
Corresponding Author	Fabio Ferrari Makdissi, PhD, Department of Gastroenterology, Instituto do Cancer, Hospital das Clínicas, Faculdade de Medicina, Universidade de São Paulo, Av Dr Arnaldo, 251, São Paulo 01246000, Brazil. fabio.makdissi@hc.fm.usp.br
Key Words	Gallbladder neoplasms; Biliary tract neoplasms; Adenocarcinoma; Survival; Prognostic factors; Incidental cancer; Surgical oncology; Brazil
Core Tip	This retrospective study evaluated the clinicopathological characteristic, treatment strategies, and survival outcomes of patients with gallbladder carcinoma (GBC) treated at a high-volume cancer center in Brazil. Most patients presented with advanced-stage disease, limiting curative options. Incidental GBC was more frequent than non-incidental cases and associated with significantly better survival. Radical surgery, although feasible in a minority, provided the best long-term outcomes. These findings highlight the importance of early detection and timely referral to specialized hepatobiliary centers to improve prognosis in GBC.
Citation	Makdissi FF, Kawakami LE, Pereira MA, Kruguer JAP, Marques GF, Coelho FF, Jukemura J, Herman P. Gallbladder carcinoma in Brazil: Clinicopathological profile and survival outcomes from a high-volume cancer center. World J Gastroenterol 2025; In press

Received	2025-09-05 09:51
Peer-Review Started	2025-09-05 09:52
First Decision by Editorial Office Director	2025-10-13 09:25
Return for Revision	2025-10-13 09:25
Revised	2025-10-25 03:12
Publication Fee Transferred
Second Decision by Editor	2025-12-09 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-10 01:29
Articles in Press	2025-12-10 01:29
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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