Publication Name	World Journal of Clinical Oncology
Manuscript ID	113857
Country	China

Category	Oncology
Manuscript Type	Letter to the Editor
Article Title	Endoscopic submucosal dissection in early esophageal neoplasia: Celebrating efficacy, confronting heterogeneity, and refining surveillance for high-risk patients
Manuscript Source	Invited Manuscript
All Author List	Shi-Qiong Zhou and Qing-Hua Ke
Funding Agency and Grant Number
Corresponding Author	Qing-Hua Ke, Chief Physician, PhD, Department of Chemoradiotherapy, Jingzhou No. 1 People’s Hospital and First Affiliated Hospital of Yangtze University, No. 10 Tianhu Road, Shashi District, Jingzhou 434000, Hubei Province, China. 3803354759@qq.com
Key Words	Early esophageal neoplasia; Endoscopic submucosal dissection; Lesion heterogeneity; Surveillance; Esophageal stricture
Core Tip	This article explores early esophageal neoplastic lesions (low/high-grade intraepithelial neoplasia, early/superficial carcinoma) treated with endoscopic submucosal dissection , revealing heterogeneity in endoscopic/pathological features, curative resection rate, and prognosis. Key factors include non-curative resection, esophageal stricture, age, and prior cancer history. Biomarkers (Ki-67, p53) differ by lesion grade, correlating with invasion and treatment response, informing stratified management, adjuvant therapy, and personalized surveillance.
Citation	Zhou SQ, Ke QH. Endoscopic submucosal dissection in early esophageal neoplasia: Celebrating efficacy, confronting heterogeneity, and refining surveillance for high-risk patients. World J Clin Oncol 2025; In press

Received	2025-09-05 08:25
Peer-Review Started	2025-09-05 08:25
First Decision by Editorial Office Director	2025-09-25 09:16
Return for Revision	2025-09-25 23:55
Revised	2025-09-27 03:24
Publication Fee Transferred
Second Decision by Editor	2025-12-15 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-15 11:08
Articles in Press	2025-12-15 11:08
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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