| Category |
Psychiatry |
| Manuscript Type |
Prospective Study |
| Article Title |
Visuospatial memory modulates insight and its predictive value for 6-year psychosis risk in clinical high-risk individuals
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Li-Hua Xu, Hui-Ru Cui, Yan-Yan Wei, Xiao-Chen Tang, Zhen-Ying Qian, Dan Zhang, Wen-Si Zheng, Tian-Yuan Zhu, Xiang-Fei Hong, Jun-Juan Zhu, Ye-Gang Hu, Liu Xu, Xiong Jiao, Ying Qing, Xiao-Chen Chen, Ying-Ying Tang, Tian-Hong Zhang and Ji-Jun Wang |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Ministry of Science and Technology of China, National Key RD Program of China |
No. 2023YFC2506800 |
| Science and Technology Commission of Shanghai Municipality |
No. 23Y11900500 |
| Science and Technology Commission of Shanghai Municipality |
No. 23Y11906000 |
| Science and Technology Commission of Shanghai Municipality |
No. 23Y11906100 |
| Shanghai Municipal Health Commission |
No. 202340015 |
| Shanghai Mental Health Center |
No. CRC2018YB01 |
| Shanghai Mental Health Center |
No. 2024-QM02 |
|
| Corresponding Author |
Ji-Jun Wang, Director, PhD, Professor, Neuromodulation Center, Shanghai Mental Health Center, No. 600 Wanping South Road, Shanghai 200030, China. jijunwang27@163.com |
| Key Words |
Marginal effects; Conversion risk; Clinical high risk for psychosis; Visuospatial memory; Impaired insight |
| Core Tip |
Impaired insight predicts psychosis in individuals at clinical high risk (CHR), yet its neurocognitive underpinnings remain unclear. In a six-year follow-up of 312 CHR participants, visuospatial memory assessed via the Brief Visuospatial Memory Test-Revised (BVMT-R) emerged as the key cognitive domain differentiating low and high impaired insight groups, independent of positive symptoms. Notably, higher BVMT-R scores reduced the risk of conversion to psychosis, moderating the impact of impaired insight. These findings highlight visuospatial memory as a potential marker for identifying CHR individuals at greatest risk and suggest targeted cognitive interventions to enhance insight and mitigate psychosis onset. |
| Citation |
Xu LH, Cui HR, Wei YY, Tang XC, Qian ZY, Zhang D, Zheng WS, Zhu TY, Hong XF, Zhu JJ, Hu YG, Xu L, Jiao X, Qing Y, Chen XC, Tang YY, Zhang TH, Wang JJ. Visuospatial memory modulates insight and its predictive value for 6-year psychosis risk in clinical high-risk individuals. World J Psychiatry 2026; In press |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
