Publication Name	World Journal of Nephrology
Manuscript ID	113875
Country	Peru

Category	Endocrinology & Metabolism
Manuscript Type	Review
Article Title	Endocrine disorders linked to chronic kidney disease: Mechanisms and clinical implications
Manuscript Source	Invited Manuscript
All Author List	Marcio J Concepción-Zavaleta, Jenyfer M Fuentes-Mendoza, Elida P López-Ramírez, Jesús A Martínez-García, Luis A Concepción-Urteaga and José Paz-Ibarra
Funding Agency and Grant Number
Corresponding Author	Marcio J Concepción-Zavaleta, Grupo de investigación en Neurociencias, Metabolismo, Efectividad Clínica y Sanitaria, Universidad Científica del Sur, 19 Panamericana Sur Km, Villa El Salvador, Lima 15067, Peru. mconcepcion@cientifica.edu.pe
Key Words	Chronic kidney disease; Endocrine dysfunction; Hormonal imbalance; Chronic kidney disease-mineral and bone disorder; Hypogonadism; Insulin resistance
Core Tip	Chronic kidney disease disrupts multiple endocrine pathways, leading to mineral and bone disorders, thyroid dysfunction, hypogonadism, insulin resistance, and prolactin elevation. These hormonal disturbances exacerbate cardiovascular disease, anemia, sarcopenia, and impaired quality of life. This narrative review synthesizes current evidence on mechanisms, diagnostic challenges, and therapeutic strategies for endocrine complications in chronic kidney disease. By highlighting the bidirectional relationship between kidney and endocrine dysfunction, it underscores the need for integrated nephrology-endocrinology management to optimize patient outcomes.
Citation	Concepción-Zavaleta MJ, Fuentes-Mendoza JM, López-Ramírez EP, Martínez-García JA, Concepción-Urteaga LA, Paz-Ibarra J. Endocrine disorders linked to chronic kidney disease: Mechanisms and clinical implications. World J Nephrol 2025; In press

Received	2025-09-05 03:22
Peer-Review Started	2025-09-05 03:22
First Decision by Editorial Office Director	2025-09-17 08:28
Return for Revision	2025-09-17 08:28
Revised	2025-09-26 21:46
Publication Fee Transferred
Second Decision by Editor	2025-12-15 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-15 07:59
Articles in Press	2025-12-15 07:59
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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