Publication Name	World Journal of Hepatology
Manuscript ID	113896
Country	Germany

Category	Medicine, Research & Experimental
Manuscript Type	Basic Study
Article Title	Transforming growth factor beta reduces proprotein convertase subtilisin/kexin type 9 in the supernatant of hepatic stellate cells
Manuscript Source	Unsolicited Manuscript
All Author List	Jan Bundschuh, Maximilian Neumann, Sebastian Zimny, Marlen Spirk and Christa Buechler
Funding Agency and Grant Number
Corresponding Author	Christa Buechler, Associate Professor, PhD, Senior Researcher, Department of Internal Medicine I, University Hospital Regensburg, Franz-Josef-Strauss Allee 11, Regensburg 93053, Bavaria, Germany. christa.buechler@klinik.uni-regensburg.de
Key Words	Hepatic stellate cells; Kupffer cells; Leptin; Lipopolysaccharide; Transforming growth factor beta; Proprotein convertase subtilisin/kexin type 9; Liver X receptor
Core Tip	This study showed that primary hepatic stellate cells and the LX-2 cell line secrete proprotein convertase subtilisin/kexin type 9 (PCSK9). Levels of PCSK9 in the medium of LX-2 cells were found to be reduced by interleukin-6, chemerin-156, and transforming growth factor beta, and increased by lipopolysaccharide. The liver X receptor agonist lowered PCSK9 levels in the cell medium. As transforming growth factor beta is a fibrotic cytokine and activation of the liver X receptor exerts antifibrotic effects, PCSK9 levels in the cell medium cannot be used as a marker of activated hepatic stellate cells.
Citation	Bundschuh J, Neumann M, Zimny S, Spirk M, Buechler C. Transforming growth factor beta reduces proprotein convertase subtilisin/kexin type 9 in the supernatant of hepatic stellate cells. World J Hepatol 2025; In press

Received	2025-09-08 05:37
Peer-Review Started	2025-09-08 05:37
To Make the First Decision
Return for Revision	2025-09-30 08:06
Revised	2025-10-10 11:50
Second Decision	2025-11-25 02:38
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-26 03:26
Articles in Press	2025-11-26 03:26
Publication Fee Transferred	2025-10-18 08:01
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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