Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	113918
Country	Greece

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Endoscopic submucosal dissection: Challenges, innovations, and the road ahead
Manuscript Source	Invited Manuscript
All Author List	Miltiadis K Moutzoukis, Anastasios Manolakis, Andreas Kapsoritakis, Dimitrios Christodoulou and Konstantinos Argyriou
Funding Agency and Grant Number
Corresponding Author	Konstantinos Argyriou, Department of Gastroenterology, University Hospital of Larisa, Mezourlo, Larisa 41100, Greece. kosnar2@yahoo.gr
Key Words	Endoscopic submucosal dissection; Gastrointestinal neoplasms; Treatment outcome; Learning curve; Technological innovation; Future directions
Core Tip	Endoscopic submucosal dissection enables curative, organ-preserving treatment of early gastrointestinal neoplasia, but its adoption is limited by technical complexity, long procedure times, and uneven training opportunities. Recent advances including novel dissection tools, traction methods, and digital training along with emerging technologies such as artificial intelligence and robotics, have the potential to overcome these barriers. Future progress will depend on both technological innovation and system-level strategies to expand training and standardize practice worldwide.
Citation	Moutzoukis MK, Manolakis A, Kapsoritakis A, Christodoulou D, Argyriou K. Endoscopic submucosal dissection: Challenges, innovations, and the road ahead. World J Gastrointest Endosc 2025; In press

Received	2025-09-07 15:04
Peer-Review Started	2025-09-07 15:04
To Make the First Decision
Return for Revision	2025-09-25 09:04
Revised	2025-10-09 22:21
Second Decision	2025-11-21 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-21 03:44
Articles in Press	2025-11-21 03:44
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5190 (online)
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