Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	113922
Country	China

Category	Oncology
Manuscript Type	Clinical Trials Study
Article Title	Clinical efficacy of Fuzheng Jiedu Xiaoyong granules in advanced colorectal cancer (spleen deficiency and stasis toxin syndrome)
Manuscript Source	Unsolicited Manuscript
All Author List	Hai-Yun Qin, Zheng Li, Pei-Wei Cong, Dan Mi, Feng-Zhen Li, Xin Hu and Guo-Xin Li
Funding Agency and Grant Number
Corresponding Author	Guo-Xin Li, Chief Physician, PhD, Professor, Guoyi Hall, The Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, No. 60, Huanghe North Street, Huanggu District, Shenyang City, Liaoning Province, China, Shenyang 110034, Liaoning Province, China. syyljdlgx024@126.com
Key Words	Advanced colorectal cancer; Fuzheng Jiedu Xiaoyong granules; First-line therapy; Randomized controlled trial; Immune function
Core Tip	The combination of Fuzheng Jiedu Xiaoyong granules (FZJDXYG) with first-line therapy for advanced colorectal cancer (CRC) demonstrates significant clinical efficacy with minimal adverse effects. It has effectively modulated immune dysfunction and improved patients’ quality of life. A parallel, randomized, controlled trial confirmed the significant efficacy and high safety of FZJDXYG in treating advanced CRC patients. Moreover, FZJDXYG significantly increased the CD4+ T cell ratio, reduced the CD8+ T cell ratio, and elevated the CD4+/CD8+ ratio in patients, with significant differences both before and after treatment, as well as between the treatment and control group.
Citation	Qin HY, Li Z, Cong PW, Mi D, Li FZ, Hu X, Li GX. Clinical efficacy of Fuzheng Jiedu Xiaoyong granules in advanced colorectal cancer (spleen deficiency and stasis toxin syndrome). World J Gastrointest Oncol 2025; In press

Received	2025-10-14 09:10
Peer-Review Started	2025-10-14 09:10
First Decision by Editorial Office Director	2025-10-24 06:33
Return for Revision	2025-10-24 06:33
Revised	2025-11-21 06:36
Publication Fee Transferred	2025-11-24 11:53
Second Decision by Editor	2025-12-18 02:40
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-18 07:55
Articles in Press	2025-12-18 07:55
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Typeset the Manuscript

ISSN	1948-5204 (online)
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