Publication Name	World Journal of Stem Cells
Manuscript ID	113924
Country	Egypt

Category	Biology
Manuscript Type	Letter to the Editor
Article Title	Exercise with induced pluripotent stem cells enhances Wnt1-Lmx1a signaling and dopaminergic neurogenesis to alleviate Parkinsonian symptoms
Manuscript Source	Invited Manuscript
All Author List	Aya Arafat, Soliman Mehawed Abdellatif Soliman, Thoraya A Farghaly and Noura A A Ebrahim
Funding Agency and Grant Number
Corresponding Author	Noura A A Ebrahim, Department of Oncologic Pathology, National Cancer Institute, Cairo University, 1st Kasr Alainy Street, Cairo 11796, Al Qāhirah, Egypt. npathologist@gmail.com
Key Words	Parkinson’s disease; Induced pluripotent stem cells; Exercise; Wnt1-Lmx1a signaling; Dopaminergic neurogenesis; Biomaterials; Neuroregeneration; Stem cell transplantation
Core Tip	This letter builds on Jiang et al’s recent findings that voluntary exercise enhances the therapeutic impact of induced pluripotent stem cell transplantation in Parkinson’s disease by activating the Wnt1-Lmx1a pathway. We highlight exercise as a molecular modulator that fosters a neurogenic milieu, recommend examining additional developmental signals (sonic hedgehog, fibroblast growth factor 8, bone morphogenetic protein), and suggest biomaterial-based strategies to support graft survival and integration. We also stress the need to optimize exercise regimens in relation to transplantation, framing these insights within a translational strategy for advancing regenerative therapies in Parkinson’s disease.
Citation	Arafat A, Soliman SMA, Farghaly TA, Ebrahim NAA. Exercise with induced pluripotent stem cells enhances Wnt1-Lmx1a signaling and dopaminergic neurogenesis to alleviate Parkinsonian symptoms. World J Stem Cells 2025; In press

Received	2025-09-07 07:21
Peer-Review Started	2025-09-07 07:21
First Decision by Editorial Office Director	2025-09-30 08:01
Return for Revision	2025-09-30 08:01
Revised	2025-10-25 19:19
Publication Fee Transferred
Second Decision by Editor	2025-12-02 02:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-03 03:49
Articles in Press	2025-12-03 03:49
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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