Publication Name	World Journal of Gastroenterology
Manuscript ID	113939
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Cohort Study
Article Title	Role of hepatic sonic hedgehog protein expression in the diagnosis of metabolic dysfunction-associated steatohepatitis
Manuscript Source	Unsolicited Manuscript
All Author List	Xu Han, Miao-Yang Chen, Qing-Fang Xiong, Yan-Dan Zhong, Du-Xian Liu, Jia Li and Yong-Feng Yang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81970454 Key Projects of Jiangsu Provincial Health Commission ZD2021061
Corresponding Author	Yong-Feng Yang, Chief Physician, PhD, Professor, Department of Infectious Disease and Liver Disease, The Second Hospital of Nanjing, Nanjing University of Chinese Medicine, No. 1 Zhongfu Road, Gulou District, Nanjing 210003, Jiangsu Province, China. yangyongfeng@njucm.edu.cn
Key Words	Metabolic dysfunction-associated steatotic liver disease; Metabolic dysfunction-associated steatohepatitis; Ballooned hepatocytes; Cytokeratin 8/18; Sonic hedgehog
Core Tip	This is a retrospective cohort study of the characteristics of metabolic dysfunction-associated steatohepatitis, in which we found the suggestive role of sonic hedgehog immunostaining in the diagnosis of metabolic dysfunction-associated steatohepatitis. We also found that histological ballooning hepatocytes and circulating M30 as independent predictors of advanced fibrosis.
Citation	Han X, Chen MY, Xiong QF, Zhong YD, Liu DX, Li J, Yang YF. Role of hepatic sonic hedgehog protein expression in the diagnosis of metabolic dysfunction-associated steatohepatitis. World J Gastroenterol 2026; In press

Received	2025-09-08 10:35
Peer-Review Started	2025-09-08 10:36
First Decision by Editorial Office Director	2025-10-11 07:20
Return for Revision	2025-10-11 07:20
Revised	2025-10-24 17:33
Publication Fee Transferred	2025-10-28 14:23
Second Decision by Editor	2026-01-28 02:43
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-28 09:21
Articles in Press	2026-01-28 09:21
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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