| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Risk prediction for chronic atrophic gastritis using a random forest model: A multicenter study
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hui Cao, Jing-Lue Han, Hao Wu, Shu-Ping Si, Li-Jia Ding, Lin Ji, Hua-Zhen Zhang, Jie Yin, Zhi-Yi Zhou, Yu-Nan Zhang, Zhi-Fa Lv, Wen-Ying Tian, Qiang Zhan, Hui Wang and Fang-Mei An |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Wuxi "Double Hundred" Young and Middle-aged Medical Talents Project |
BJ2023008 |
| the Wuxi Medical Center of Nanjing Medical University Special Disease Cohort and Clinical Research Project |
WMCC202502 |
| the Wuxi Medical Center of Nanjing Medical University Key Project |
WMCM202501 |
| the Jiangsu Branch of the National Clinical Research Center for Digestive Diseases |
JSZX202301 |
|
| Corresponding Author |
Fang-Mei An, Associate Chief Physician, Associate Professor, MD, Department of Gastroenterology, Affiliated Wuxi People’s Hospital of Nanjing Medical University, No. 299 Qingyang Road, Liangxi District, Wuxi 214000, Jiangsu Province, China. fangmeian@njmu.edu.cn |
| Key Words |
Chronic atrophic gastritis; Machine learning; Risk prediction; Gastric cancer screening; Random forest |
| Core Tip |
This study addresses the need for a noninvasive method to screen for chronic atrophic gastritis (CAG), a key precancerous condition of gastric cancer (GC). We developed and validated a random forest machine learning model using data from 1268 subjects. The model accurately predicts CAG risk using six easily obtainable features: Helicobacter pylori infection status, age, pepsinogen ratio, smoking history, alcohol use history, and family history of GC. The model demonstrated high accuracy and generalizability (area under the curve > 0.85). A user-friendly web calculator was created for clinical application, providing a practical tool for the early identification of high-risk individuals. |
| Citation |
Cao H, Han JL, Wu H, Si SP, Ding LJ, Ji L, Zhang HZ, Yin J, Zhou ZY, Zhang YN, Lv ZF, Tian WY, Zhan Q, Wang H, An FM. Risk prediction for chronic atrophic gastritis using a random forest model: A multicenter study. World J Gastrointest Oncol 2025; In press |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
