Publication Name	World Journal of Gastroenterology
Manuscript ID	113985
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	Exercise-responsive skeletal muscle genes mechanistically linked to metabolic dysfunction-associated steatotic liver disease
Manuscript Source	Unsolicited Manuscript
All Author List	Jia-Hui Zhang, Kang Chen, Xiao-Min Zhu, Huan Zhou, Jia-Mi Jiang, Yu-Qing Zou, Ke-Rong Liu, Le Zhang and Yun Li
Funding Agency and Grant Number	Funding Agency Grant Number Wuxi Science and Technology Development Fund No. K20241001 Wuxi Science and Technology Development Fund No. Y20232026 Jiangsu Medical Association Pediatric Medicine Phase II Scientific Research Special Fund Project No. SYH-32034-0106 (2024010) Top Talent Support Program for Young and Middle-Aged People of Wuxi Health Committee No. HB2023091 Top Talent Support Program for Young and Middle-Aged People of Wuxi Health Committee No. BJ2023090 Medical Key Discipline Program of Wuxi Health Commission No. ZDXK2021007
Corresponding Author	Yun Li, PhD, Research Assistant Professor, Department of Pediatric Laboratory, Affiliated Children’s Hospital of Jiangnan University, Wuxi Children’s Hospital, Wuxi Key Laboratory of Genetic and Metabolic Diseases in Children, No. 299 Qingyang Road, Liangxi District, Wuxi 214023, Jiangsu Province, China. yunli_med@jiangnan.edu.cn
Key Words	Metabolic dysfunction-associated steatotic liver disease; Myokines; Weighted gene co-expression network analysis; LAMA4; PECAM1; PXDN; THBS4
Core Tip	This study identified four exercise-responsive skeletal muscle-expressed genes (LAMA4, PECAM1, PXDN and THBS4), which were mechanistically linked to metabolic dysfunction-associated steatotic liver disease (MASLD). These genes may serve as myokine-like candidates, shedding light on the molecular pathways by which exercise mediates metabolic adaptation in MASLD. The findings provided novel insights into the pathophysiology of MASLD and suggested these biomarkers as promising candidates for precision diagnostics and therapeutic interventions.
Citation	Zhang JH, Chen K, Zhu XM, Zhou H, Jiang JM, Zou YQ, Liu KR, Zhang L, Li Y. Exercise-responsive skeletal muscle genes mechanistically linked to metabolic dysfunction-associated steatotic liver disease. World J Gastroenterol 2026; In press

Received	2025-09-11 02:45
Peer-Review Started	2025-09-11 02:45
First Decision by Editorial Office Director	2025-09-30 09:48
Return for Revision	2025-09-30 09:48
Revised	2025-11-17 07:45
Publication Fee Transferred	2025-11-21 15:31
Second Decision by Editor	2026-01-12 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-12 09:25
Articles in Press	2026-01-12 09:25
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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