Publication Name	World Journal of Stem Cells
Manuscript ID	114032
Country	China

Category	Cell & Tissue Engineering
Manuscript Type	Basic Study
Article Title	Epiregulin enhances periodontal tissue regeneration by promoting bone marrow mesenchymal stem cells functions under inflammatory niches
Manuscript Source	Unsolicited Manuscript
All Author List	Ying-Chu Zhao, Guo-Yue Li, Si Chen, Yi-Lin Wang, Jing-Yi Feng and Yu Cao
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81670948
Corresponding Author	Yu Cao, PhD, Professor, Vice Director, Department of Wangfujing General School of Stomatology, Capital Medical University School of Stomatology, No. 11 Pewter Lane, Dongcheng District, Beijing 100010, China. caoyu_bj@163.com
Key Words	Inflammatory conditions; Bone marrow mesenchymal stem cells; Epiregulin; Periodontal tissue regeneration; Epiregulin-epidermal growth factor receptor-extracellular signal-regulated kinase 1/2 pathway; Inflammatory niche
Core Tip	Enhancing the function of the repaired stem cells in the inflammatory niche is crucial for periodontal tissue regeneration. This study revealed that epiregulin (EREG) enhanced the migration, chemotaxis, and osteogenesis of mouse bone marrow stem cells under inflammatory conditions. Furthermore, EREG activates the extracellular signal-regulated kinase 1/2 pathway by binding to epidermal growth factor receptor. Disruption of this pathway affected the function of mouse bone marrow stem cells. Finally, the local injection of EREG promoted periodontal tissue regeneration. These findings suggest a novel therapeutic strategy for the treatment of periodontitis.
Citation	Zhao YC, Li GY, Chen S, Wang YL, Feng JY, Cao Y. Epiregulin enhances periodontal tissue regeneration by promoting bone marrow mesenchymal stem cells functions under inflammatory niches. World J Stem Cells 2026; In press

Received	2025-09-10 08:04
Peer-Review Started	2025-09-10 08:08
First Decision by Editorial Office Director	2025-09-28 09:29
Return for Revision	2025-09-28 09:29
Revised	2025-10-20 15:32
Publication Fee Transferred	2025-10-23 09:49
Second Decision by Editor	2026-01-13 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-14 09:23
Articles in Press	2026-01-14 09:23
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Typeset the Manuscript

ISSN	1948-0210 (online)
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