Publication Name	World Journal of Psychiatry
Manuscript ID	114036
Country	China

Category	Psychiatry
Manuscript Type	Observational Study
Article Title	Clinical symptom improvement following modified electroconvulsive therapy is associated with modulation of peripheral inflammatory markers in schizophrenia
Manuscript Source	Unsolicited Manuscript
All Author List	Lu Hou, Ru Chen, Cheng-Bing Huang, Wen-Jie Shi and Li-Li Wu
Funding Agency and Grant Number
Corresponding Author	Wen-Jie Shi, Academic Fellow, Chief Physician, Department of Psychiatry, Huai’an Third People’s Hospital, No. 272 Huaihai West Road, Huai’an 223001, Jiangsu Province, China. shiwenjie197948@126.com
Key Words	Modified electroconvulsive therapy; Schizophrenia; Immunoinflammation; Monocyte-to-lymphocyte ratio; Positive and Negative Syndrome Scale score reduction rate
Core Tip	This study demonstrates that modified electroconvulsive therapy significantly improves clinical symptoms and reduces peripheral inflammatory markers - including monocyte-to-lymphocyte ratio (MLR), neutrophil-to-lymphocyte ratio, and systemic immune-inflammatory indices - in patients with schizophrenia. Reductions in MLR were strongly correlated with clinical improvement and served as a robust predictor of treatment response. Specifically, each 0.1-unit increase in ΔMLR was associated with a 57% higher likelihood of significant symptom improvement. These findings suggest an immunomodulatory mechanism of modified electroconvulsive therapy and support the use of MLR as a potential biomarker for predicting treatment efficacy.
Citation	Hou L, Chen R, Huang CB, Shi WJ, Wu LL. Clinical symptom improvement following modified electroconvulsive therapy is associated with modulation of peripheral inflammatory markers in schizophrenia. World J Psychiatry 2025; In press

Received	2025-09-11 07:52
Peer-Review Started	2025-09-11 07:52
First Decision by Editorial Office Director	2025-10-10 03:18
Return for Revision	2025-10-10 03:18
Revised	2025-10-21 09:20
Publication Fee Transferred	2025-10-25 10:25
Second Decision by Editor	2025-12-02 02:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-02 06:30
Articles in Press	2025-12-02 06:30
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3206 (online)
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