Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	114040
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Tight junction proteins: Gatekeepers turned facilitators in the pathogenesis of gastric adenocarcinoma
Manuscript Source	Invited Manuscript
All Author List	Shobha Selvam and Balasubramaniyan Vairappan
Funding Agency and Grant Number
Corresponding Author	Balasubramaniyan Vairappan, Additional Professor, PhD, Department of Biochemistry, Jawaharlal Institute of Postgraduate Medical Education and Research, Dhanvantari Nagar, Pondicherry 605006, India. balasubramaniyan.v@jipmer.edu.in
Key Words	Claudins; Gastric cancer; Infection and inflammation; Occludin and zonula occludens; Tight junction
Core Tip	Tight junction (TJ) proteins play a pivotal role in preserving the integrity of the gastric epithelial barrier. Their dysregulation represents a critical early event linking chronic inflammation to gastric carcinogenesis. Inflammatory mediators induce TJ remodeling, thereby increasing mucosal permeability and promoting tumor initiation and progression. Emerging therapeutic strategies targeting TJ proteins either by pharmacologically restoring barrier integrity or modulating aberrant TJ signaling offer promising avenues to suppress inflammation, inhibit tumor growth and metastasis, and ultimately improve clinical outcomes in gastric cancer patients.
Citation	Selvam S, Vairappan B. Tight junction proteins: Gatekeepers turned facilitators in the pathogenesis of gastric adenocarcinoma. World J Gastrointest Oncol 2025; In press

Received	2025-09-10 08:19
Peer-Review Started	2025-09-10 08:21
To Make the First Decision
Return for Revision	2025-09-29 10:35
Revised	2025-10-21 08:01
Second Decision	2025-11-24 02:42
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-24 07:18
Articles in Press	2025-11-24 07:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com