Publication Name	World Journal of Diabetes
Manuscript ID	114042
Country	Australia

Category	Endocrinology & Metabolism
Manuscript Type	Minireviews
Article Title	From lipodystrophy to subcutaneous insulin depots: Overlooked mechanisms of glycemic variability in patients with diabetes
Manuscript Source	Invited Manuscript
All Author List	Nhi Thi Y Nguyen, Hau Phuc Tran, Thang Viet Luong, Dat Xuan Nguyen, Duong Hung Tran, Phuong Ho Thi Hoai, Meng-Chi Lee and Hai Nguyen Ngoc Dang
Funding Agency and Grant Number
Corresponding Author	Hai Nguyen Ngoc Dang, Menzies Institute for Medical Research, University of Tasmania, 1/17 Liverpool Street, Hobart 7000, Tasmania, Australia. ngochai123dc@gmail.com
Key Words	Insulin depot; Lipohypertrophy; Lipodystrophy; Insulin absorption; Injection technique; Ultrasound; Diabetes
Core Tip	Lipohypertrophy is a common but often overlooked cause of unstable insulin activity. Tissue hypertrophy and fibrosis at injection sites can create insulin depot behavior, leading to delayed and unpredictable absorption with both hyperglycemia and late hypoglycemia. A practical management pathway combines routine injection-site inspection with palpation (and ultrasound when needed), structured rotation and technique education, and close monitoring with individualized dose adjustment when patients are switched away from affected areas. Embedding injection-site care into routine insulin titration can reduce avoidable glycemic variability and improve insulin safety.
Citation	Nguyen NTY, Tran HP, Luong TV, Nguyen DX, Tran DH, Hoai PHT, Lee MC, Dang HNN. From lipodystrophy to subcutaneous insulin depots: Overlooked mechanisms of glycemic variability in patients with diabetes. World J Diabetes 2026; In press

Received	2025-09-10 06:04
Peer-Review Started	2025-09-15 00:27
First Decision by Editorial Office Director	2025-10-27 09:16
Return for Revision	2025-10-27 09:16
Revised	2026-03-10 19:48
Publication Fee Transferred
Second Decision by Editor	2026-03-26 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-03-26 03:53
Articles in Press	2026-03-26 03:53
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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Copyright	©Author(s) (or their employer(s)) 2026. No commercial re-use. See Permissions. Published by Baishideng Publishing Group Inc.
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