Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	114054
Country	Kazakhstan

Category	Pediatrics
Manuscript Type	Systematic Reviews
Article Title	Proteomic biomarkers for early diagnosis and prognosis in pediatric sepsis
Manuscript Source	Unsolicited Manuscript
All Author List	Guldana Sabitova, Zhalaliddin Makhammajanov, Marina Khvan, Pavel Tarlykov and Vitaliy Sazonov
Funding Agency and Grant Number	Funding Agency Grant Number Nazarbayev University Faculty Development Grant for 2025-2027 No. 040225FD4716
Corresponding Author	Vitaliy Sazonov, Assistant Professor, MD, Department of Surgery, School of Medicine, Nazarbayev University, Kabanbay Batyr 53, Astana Z05K4F4, Kazakhstan. vitaliy.sazonov@nu.edu.kz
Key Words	Sepsis; Pediatric sepsis; Biomarkers; Proteomics; Multi-omics; Pediatric intensive care unit; Pediatrics
Core Tip	Pediatric sepsis requires rapid and reliable "rule-in" tools upon presentation. This systematic review summarizes four pediatric proteomics studies and presents a practical pathway. Single markers, such as interleukin-27, serum amyloid A 1, soluble CD25, and leucine-rich alpha-2-glycoprotein 1, demonstrate high specificity for early diagnosis. The infant-focused combination of haptoglobin and thrombospondin 1 improves short-term risk stratification. We explain why age matters: Noting that immune maturation shifts effect sizes and may necessitate age-adjusted cut-points and neonatal-specific panels. We also map discovery platforms (aptamer/mass spectrometry) to rapid 3-5-plex immunoassays that are suitable for emergency department and pediatric intensive care unit use. Rather than offering pooled estimates, the systematic review provides translational guidance aimed at accelerating the deployment of clinically useful pediatric sepsis testing.
Citation	Sabitova G, Makhammajanov Z, Khvan M, Tarlykov P, Sazonov V. Proteomic biomarkers for early diagnosis and prognosis in pediatric sepsis. World J Clin Pediatr 2025; In press

Received	2025-09-11 07:57
Peer-Review Started	2025-09-11 07:57
To Make the First Decision
Return for Revision	2025-09-23 08:45
Revised	2025-09-29 10:27
Second Decision	2025-11-24 02:49
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-24 09:57
Articles in Press	2025-11-24 09:57
Publication Fee Transferred	2025-10-02 09:47
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Typeset the Manuscript

ISSN	2219-2808 (online)
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