Publication Name	World Journal of Diabetes
Manuscript ID	114061
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Basic Study
Article Title	C1q tumor necrosis factor associated protein 3 protects HaCaT via phosphoinositide 3-kinase/protein kinase B activation by PTEN reduction
Manuscript Source	Unsolicited Manuscript
All Author List	Lin He, Chan Zhu, Xue-Yuan Yu, Hui-Cong Dou and Mao-Guo Shu
Funding Agency and Grant Number	Funding Agency Grant Number Key Research and Development Plan of Shaanxi Province of China No. 2023-YBSF-179 Scientific Research Fund of The First Affiliated Hospital of Xi’an Jiaotong University No. 2021ZYTS-35
Corresponding Author	Mao-Guo Shu, Department of Plastic, Aesthetic and Maxillofacial Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, No. 277 Yanta West Road, Xi’an 710061, Shaanxi Province, China. maoguoshu@xjtu.edu.cn
Key Words	Diabetes; Wound healing; C1q tumor necrosis factor associated protein 3; Protein kinase B; PTEN
Core Tip	High expression of C1q tumor necrosis factor associated protein 3 (CTRP3) promotes the wound healing of diabetic mice, and this may related to the protective effects on keratinocytes. The underlying mechanism is linked to the activation of phosphoinositide 3-kinase/protein kinase B pathway by reducing the PTEN protein level. Taken together, CTRP3 may be a novel target to accelerate the wound healing in diabetes.
Citation	He L, Zhu C, Yu XY, Dou HC, Shu MG. C1q tumor necrosis factor associated protein 3 protects HaCaT via phosphoinositide 3-kinase/protein kinase B activation by PTEN reduction. World J Diabetes 2026; In press

Received	2025-09-15 00:35
Peer-Review Started	2025-09-15 09:29
First Decision by Editorial Office Director	2025-10-30 08:40
Return for Revision	2025-10-30 08:40
Revised	2025-11-12 08:59
Publication Fee Transferred	2025-11-17 06:15
Second Decision by Editor	2026-02-06 02:46
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-02-06 10:40
Articles in Press	2026-02-06 10:40
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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