Publication Name	World Journal of Cardiology
Manuscript ID	114077
Country	Croatia

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Case Control Study
Article Title	Valvular calcification in liver cirrhosis: A comparison with non-cirrhotic cardiovascular controls
Manuscript Source	Unsolicited Manuscript
All Author List	Maja Vuckovic, Jasenka Grgurić, Frane Paic, Vedran Radonic, Ivana Jurin, Tajana Filipec Kanizaj and Tomislav Letilovic
Funding Agency and Grant Number
Corresponding Author	Frane Paic, Associate Professor, Laboratory for Epigenetic and Molecular Medicine, Department of Medical Biology, School of Medicine, University of Zagreb, Šalata 3, Zagreb 10000, Croatia. fpaic@mef.hr
Key Words	Liver cirrhosis; Aortic valve calcification; Mitral annular calcification; Metabolic associated fatty liver disease; Alcohol-related liver disease; Echocardiographic calcium scoring; Logistic regression; Risk stratification; Receiver operating characteristic analysis; Model calibration
Core Tip	In a single center observational study of 123 patients with liver cirrhosis (LC) and 123 age- and sex-matched cardiovascular controls, echocardiographic calcium scoring showed that LC - particularly metabolic associated fatty liver disease and alcohol related fatty liver disease - was independently linked to aortic valve calcification, while LC of any etiology strongly predicted mitral annular calcification. Fully adjusted models demonstrated strong discrimination and acceptable calibration, supporting their potential use for risk stratification in LC clinics. These models may help flag high-risk patients who warrant closer echocardiographic surveillance, pending external validation.
Citation	Vuckovic M, Grgurić J, Paic F, Radonic V, Jurin I, Filipec Kaniza T, Letilovic T. Valvular calcification in liver cirrhosis: A comparison with non-cirrhotic cardiovascular controls. World J Cardiol 2026; In press

Received	2025-09-11 02:42
Peer-Review Started	2025-09-11 02:42
First Decision by Editorial Office Director	2025-10-13 08:14
Return for Revision	2025-10-13 08:14
Revised	2025-11-14 08:12
Publication Fee Transferred	2025-11-21 13:45
Second Decision by Editor	2026-01-09 02:42
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-09 03:50
Articles in Press	2026-01-09 03:50
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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