Publication Name	World Journal of Hepatology
Manuscript ID	114088
Country	China

Category	Food Science & Technology
Manuscript Type	Letter to the Editor
Article Title	Advancing mechanistic and translational insights into ginger-extract-mediated protection against acrylamide-induced liver injury
Manuscript Source	Invited Manuscript
All Author List	Xu Cui, Zhi-Qiang Chen and Liu Chen
Funding Agency and Grant Number	Funding Agency Grant Number Fujian Provincial Science and Technology Innovation Joint Fund Project No. 2024Y9555 Youth Research Project of the Science and Technology Plan of Fujian Provincial Health Commission No. 2024QNB005 Fujian Provincial Natural Science Foundation Project No. 2025J01226 Fuian Provincial Medical Project for Creating Dual High-Quality Development (High Level and High Standard) No. ETK2025004
Corresponding Author	Xu Cui, Department of Pediatric Surgery, Fujian Children’s Hospital (Fujian Branch of Shanghai Children’s Medical Center), College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, No. 18 Daoshan Road, Fuzhou 350001, Fujian Province, China. 16802937@qq.com
Key Words	Ginger extract; Acrylamide-induced liver injury; Metabolomics; Hepatoprotection; Therapeutic agents
Core Tip	This article highlights critical gaps in current research on ginger extract's hepatoprotective effects against acrylamide-induced liver injury - namely, the undefined material basis of active components and superficial mechanistic insights. It proposes actionable solutions: Leveraging portal venous metabolomics, liver liquid chromatography-mass spectrometry profiling, and single-cell transcriptomics to map protective metabolites and molecular changes; validating mechanisms via primary hepatocyte assays (apoptosis, inflammation, oxidative stress); and applying high-throughput screening (genetic editing) to uncover target pathways. These directions are pivotal to transforming phenotypic observations into mechanistically robust, translatable insights for ginger-based liver protection.
Citation	Cui X, Chen ZQ, Chen L. Advancing mechanistic and translational insights into ginger-extract-mediated protection against acrylamide-induced liver injury. World J Hepatol 2026; In press

Received	2025-09-15 02:42
Peer-Review Started	2025-09-15 02:42
First Decision by Editorial Office Director	2025-11-04 08:06
Return for Revision	2025-11-04 08:06
Revised	2025-11-12 00:24
Publication Fee Transferred
Second Decision by Editor	2026-01-08 02:37
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-08 10:00
Articles in Press	2026-01-08 10:00
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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