Publication Name	World Journal of Clinical Oncology
Manuscript ID	114107
Country	China

Category	Oncology
Manuscript Type	Minireviews
Article Title	Advances and challenges of chimeric antigen receptor T cell therapy in digestive system malignancies
Manuscript Source	Invited Manuscript
All Author List	Chen Wang, Jin Zhang, Zi-Ke Chen, Yu-Gang Wang and Min Shi
Funding Agency and Grant Number	Funding Agency Grant Number Pujiang Project of Shanghai Magnolia Talent Plan 24PJD098 Key Discipline Project of Shanghai Municipal Health System 2024ZDXK0004 Natural Science Foundation of the Science and Technology Commission of Shanghai Municipality 23ZR1458300
Corresponding Author	Min Shi, Chief Physician, MD, Professor, Department of Gastroenterology, Shanghai Tongren Hospital, Shanghai Jiao Tong University School of Medicine, No. 1111 Xianxia Road, Changning District, Shanghai 200336, China. sm1790@shtrhospital.com
Key Words	Chimeric antigen receptor T cell therapy; Digestive system tumors; Gastrointestinal cancers; Chimeric antigen receptor design; Immunotherapy
Core Tip	Chimeric antigen receptor T cell therapy (CAR) has achieved remarkable success in hematologic cancers but faces unique barriers in solid tumors of the digestive system. This article highlights recent progress in optimizing antigen selection, CAR engineering, and delivery strategies, while discussing tumor-specific targets and clinical trials in gastric, colorectal, esophageal, hepatic, and pancreatic cancers. By addressing challenges such as the tumor microenvironment and therapeutic resistance, we provide perspectives on advancing CAR T cell therapy immunotherapy toward safe, effective, and durable treatments for gastrointestinal malignancies.
Citation	Wang C, Zhang J, Chen ZK, Wang YG, Shi M. Advances and challenges of chimeric antigen receptor T cell therapy in digestive system malignancies. World J Clin Oncol 2025; In press

Received	2025-09-11 08:00
Peer-Review Started	2025-09-11 08:00
First Decision by Editorial Office Director	2025-10-11 03:25
Return for Revision	2025-10-11 03:25
Revised	2025-10-23 02:00
Publication Fee Transferred
Second Decision by Editor	2025-12-25 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-25 06:41
Articles in Press	2025-12-25 06:41
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2218-4333 (online)
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