Publication Name	World Journal of Stem Cells
Manuscript ID	114119
Country	Pakistan

Category	Cell Biology
Manuscript Type	Minireviews
Article Title	Aging puzzle: A closer look on the complex dilemma of autologous stem cell therapy
Manuscript Source	Invited Manuscript
All Author List	Mahmood S Choudhery, Taqdees Arif and Ruhma Mahmood
Funding Agency and Grant Number
Corresponding Author	Mahmood S Choudhery, Associate Professor, Department of Human Genetics and Molecular Biology, University of Health Sciences Lahore, Khayaban-e-Jamia Punjab, Block D Muslim Town, Lahore 56000, Punjab, Pakistan. ms20031@yahoo.com
Key Words	Regenerative medicine; Autologous stem cell therapy; Regenerative potential; Aging; Donor age; Optimizing therapy; Aged patients
Core Tip	Stem cell-based therapies, particularly autologous stem cell therapy, hold strong promise for treating age-related degenerative diseases by reducing risks of immune rejection and graft-vs-host disease. However, the therapeutic efficacy of patient-derived stem cells is often compromised by aging and disease-related decline in their regenerative capacity. To address these limitations, several strategies have been developed, including hypoxic preconditioning, genetic modification, growth factor supplementation, three-dimensional culturing, hybrid approaches, use of bioactive compounds, mesenchymal stem cell-derived exosomes, targeted activation of signaling pathways and cryopreservation of youthful stem cells. These approaches aim to restore or preserve stem cell functionality, enhancing therapeutic outcomes in elderly patients.
Citation	Choudhery MS, Arif T, Mahmood R. Aging puzzle: A closer look on the complex dilemma of autologous stem cell therapy. World J Stem Cells 2025; In press

Received	2025-09-12 10:09
Peer-Review Started	2025-09-12 10:09
To Make the First Decision
Return for Revision	2025-10-13 07:34
Revised	2025-10-15 12:07
Second Decision	2025-11-17 02:46
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-24 09:27
Articles in Press	2025-11-24 09:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-0210 (online)
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