Publication Name	World Journal of Cardiology
Manuscript ID	114123
Country	Nepal

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Meta-Analysis
Article Title	Comparison of 6% hydroxyethyl starch 130/0.4 vs 5% albumin in cardiopulmonary bypass for cardiac surgery
Manuscript Source	Unsolicited Manuscript
All Author List	Ahmed Alqarni, Abdulwahab Algarni and Rejina Chhetri
Funding Agency and Grant Number
Corresponding Author	Rejina Chhetri, Department of Cardiology, Nepalgunj Medical College, Das Bigha, Kohalpur - 11, Kohal 21900, Nepal. rejinachhetri01@gmail.com
Key Words	Cardiopulmonary bypass; Cardiac surgery; Hydroxyethyl starch; Albumin; Acute kidney injury; Platelet count; Blood loss
Core Tip	This meta-analysis systematically compares 6% hydroxyethyl starch 130/0.4 and 5% human albumin as priming and volume replacement fluids in cardiac surgery with cardiopulmonary bypass. It highlights comparable safety and efficacy profiles between the two colloids in terms of bleeding, transfusion needs, intensive care unit stay, and mortality, while identifying a higher risk of acute kidney injury associated with hydroxyethyl starch. These findings challenge traditional preferences and emphasize the need for individualized fluid choice guided by patient factors and evolving regulatory considerations in perioperative cardiac care.
Citation	Alqarni A, Algarni A, Chhetri R. Comparison of 6% hydroxyethyl starch 130/0.4 vs 5% albumin in cardiopulmonary bypass for cardiac surgery. World J Cardiol 2025; In press

Received	2025-09-15 08:20
Peer-Review Started	2025-09-15 08:20
First Decision by Editorial Office Director	2025-09-20 01:57
Return for Revision	2025-09-20 01:57
Revised	2025-09-22 19:48
Publication Fee Transferred
Second Decision by Editor	2025-12-01 03:10
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-01 10:22
Articles in Press	2025-12-01 10:22
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1949-8462 (online)
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