Publication Name	World Journal of Diabetes
Manuscript ID	114124
Country	India

Category	Biology
Manuscript Type	Minireviews
Article Title	Gut microbiota dysbiosis, circulating microbial genetic traces, and their role in gestational diabetes
Manuscript Source	Invited Manuscript
All Author List	Dinakaran Vasudevan
Funding Agency and Grant Number
Corresponding Author	Dinakaran Vasudevan, Senior Scientist, Gut Microbiome Division, Scientific Knowledge on Aging and Neurological Ailments (SKAN) Research Trust, Happiest Health Office, No.141/2, Gate 4, St. John’s Research Institute, 100 Feet Road, KHB Block, John Nagar, Koramangala, Bengaluru 560034, Karnataka, India. dinakaran.svgev@gmail.com
Key Words	Gut dysbiosis; Gestational diabetes mellitus; Microbial DNA; Systemic inflammation; Maternal-foetal health; Biomarkers
Core Tip	Pregnancy represents a unique metabolic state, where immune tolerance and insulin sensitivity are tightly regulated. Recent evidence suggests that gut microbiota dysbiosis may compromise the intestinal barrier, leading to the release of microbial genetic traces into the bloodstream. These microbial signals can activate host immune pathways and may aggravate systemic inflammation, thereby exacerbating gestational diabetes mellitus. This review highlights emerging insights into the link between gut dysbiosis, microbial translocation into circulation, and the worsening of diabetic outcomes in pregnancy. Understanding this gut-blood axis could open new opportunities for predictive biomarkers and targeted interventions to improve maternal and foetal health.
Citation	Vasudevan D. Gut microbiota dysbiosis, circulating microbial genetic traces, and their role in gestational diabetes. World J Diabetes 2025; In press

Received	2025-09-12 10:00
Peer-Review Started	2025-09-15 09:29
First Decision by Editorial Office Director	2025-10-11 03:04
Return for Revision	2025-10-11 03:04
Revised	2025-11-05 01:53
Publication Fee Transferred
Second Decision by Editor	2025-12-12 06:03
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-19 06:26
Articles in Press	2025-12-19 06:26
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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