Publication Name	World Journal of Nephrology
Manuscript ID	114142
Country	Türkiye

Category	Anesthesiology
Manuscript Type	Basic Study
Article Title	Protective effects of cerium oxide on ibuprofen-induced renal injury in rats with ureteral obstruction
Manuscript Source	Invited Manuscript
All Author List	Salih Toruk, Avni Babacan, Mustafa Arslan, Volkan Şıvgın, Şaban Cem Sezen and Hakan Boyunağa
Funding Agency and Grant Number
Corresponding Author	Salih Toruk, MD, Department of Anesthesiology and Reanimation, Gazi University Faculty of Medicine, No. 47 Emniyet Mh. Mevlana Blv., Ankara 06560, Türkiye. salihtoruk@gmail.com
Key Words	Cerium oxide; Ibuprofen; Non-steroidal anti-inflammatory drugs; Ureteral obstruction; Oxidative stress; Renal injury
Core Tip	This experimental study explores the protective effects of cerium oxide (CeO2), a powerful antioxidant nanoparticle, against renal injury induced by ibuprofen in rats with unilateral ureteral obstruction. Histopathological and biochemical analyses demonstrated that CeO2 significantly reduced tubular degeneration, glomerular vacuolization, and oxidative stress markers in both the obstructed and contralateral kidneys. These results indicate that CeO2 may function as a nephroprotective adjunct during non-steroidal anti-inflammatory drug therapy, potentially mitigating renal damage associated with obstructive uropathy.
Citation	Toruk S, Babacan A, Arslan M, Şıvgın V, Sezen ŞC, Boyunağa H. Protective effects of cerium oxide on ibuprofen-induced renal injury in rats with ureteral obstruction. World J Nephrol 2026; In press

Received	2025-09-12 10:26
Peer-Review Started	2025-09-12 10:26
First Decision by Editorial Office Director	2025-09-28 10:40
Return for Revision	2025-09-28 10:40
Revised	2025-10-27 19:41
Publication Fee Transferred
Second Decision by Editor	2026-01-08 02:35
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-08 07:45
Articles in Press	2026-01-08 07:45
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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