Publication Name	World Journal of Psychiatry
Manuscript ID	114153
Country	China

Category	Psychiatry
Manuscript Type	Minireviews
Article Title	Emotion-cognition dysregulation in major depression: Multidimensional biases, neural circuit imbalance, and translational opportunities
Manuscript Source	Unsolicited Manuscript
All Author List	Yi Gu, Yi-Xu Wang, Wen-Juan Xia and Jun Wang
Funding Agency and Grant Number
Corresponding Author	Jun Wang, Associate Professor, PhD, Department of Psychiatry, Wuxi Mental Health Center (Affiliated Mental Health Center of Jiangnan University), No. 156 Binhu District, Wuxi 214151, Jiangsu Province, China. woodfish2@jiangnan.edu.cn
Key Words	Major depressive disorder; Emotion-cognition dysregulation; Amygdala-prefrontal circuitry; Attentional bias; Amotion regulation; Biomarkers
Core Tip	This review reframes major depression as an emotion–cognition dysregulation syndrome characterized by a limbic-prefrontal imbalance and large-scale network disruption. By integrating behavioral signatures (negative attention/memory bias, impaired reappraisal) with neural markers (amygdala/insula hyperreactivity, weakened prefrontal control, default mode network-frontoparietal control network/salience network dyscoupling), it outlines composite biomarkers for diagnosis, stratified risk prediction, and mechanism-guided therapies (e.g., imaging-informed neuromodulation). The field now needs standardized tasks and longitudinal multimodal designs to operationalize precision psychiatry.
Citation	Gu Y, Wang YX, Xia WJ, Wang J. Emotion-cognition dysregulation in major depression: Multidimensional biases, neural circuit imbalance, and translational opportunities. World J Psychiatry 2025; In press

Received	2025-09-16 06:14
Peer-Review Started	2025-09-16 06:14
First Decision by Editorial Office Director	2025-10-17 06:56
Return for Revision	2025-10-17 06:56
Revised	2025-10-29 08:15
Publication Fee Transferred	2025-11-13 01:48
Second Decision by Editor	2025-12-09 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-09 09:04
Articles in Press	2025-12-09 09:04
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Typeset the Manuscript

ISSN	2220-3206 (online)
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