Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	114161
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Taurine suppresses gastric intestinal metaplasia in patient-derived organoids and Atp4a-/- mice
Manuscript Source	Unsolicited Manuscript
All Author List	Ke Liu, Xi Zhang, Fa-Zhan Li, Peng-Yuan Zheng and Yang Mi
Funding Agency and Grant Number	Funding Agency Grant Number Tianjian Advanced Biomedical Laboratory Key Research and Development Project Henan Province Natural Science Foundation 242300421283
Corresponding Author	Yang Mi, PhD, Henan Key Laboratory for Helicobacter pylori and Digestive Tract Microecology, The Fifth Affiliated Hospital of Zhengzhou University, No.3 Kangfu Qianjie, Erqi District, Zhengzhou 450052, Henan Province, China. yangmi198@zzu.edu.cn
Key Words	Atp4a gastric intestinal metaplasia models; Biomarkers; Gastric intestinal metaplasia; Organoid; Taurine
Core Tip	Limited treatments for gastric intestinal metaplasia (GIM) are available. This study used Atp4a-/- mice (spontaneous GIM models) and patient-derived GIM organoids to show that taurine ameliorates GIM: It reduces murine gastric mucosal lesions, upregulates the gastric marker MUC5AC, and downregulates intestinal markers (CDX2, MUC2, and TFF3) in both models, suggesting a novel GIM therapeutic strategy.
Citation	Liu K, Zhang X, Li FZ, Zheng PY, Mi Y. Taurine suppresses gastric intestinal metaplasia in patient-derived organoids and Atp4a-/- mice. World J Gastrointest Oncol 2025; In press

Received	2025-09-15 13:20
Peer-Review Started	2025-09-15 13:22
First Decision by Editorial Office Director	2025-11-18 05:29
Return for Revision	2025-11-18 05:29
Revised	2025-11-23 09:40
Publication Fee Transferred	2025-11-26 06:57
Second Decision by Editor	2025-12-16 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-16 03:28
Articles in Press	2025-12-16 03:28
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Typeset the Manuscript

ISSN	1948-5204 (online)
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