Publication Name	World Journal of Nephrology
Manuscript ID	114165
Country	India

Category	Urology & Nephrology
Manuscript Type	Prospective Study
Article Title	Dual-score framework: National Early Warning Score 2 and quick Sequential Organ Failure Assessment scores in acute pyelonephritis
Manuscript Source	Invited Manuscript
All Author List	Punith R Jain, Suryaram Aravind, Prajeeth Reddy K, Manikantan Shekar, Velmurugan Palaniyandi, Hariharasudhan Sekar and Sriram Krishnamoorthy
Funding Agency and Grant Number
Corresponding Author	Sriram Krishnamoorthy, Head, Professor, Department of Urology and Renal Transplantation, Sri Ramachandra Institute of Higher Education and Research, No. 1 Ramachandra Nagar, Porur, Chennai 600116, Tamil Nadu, India. sriram.k@sriramachandra.edu.in
Key Words	Acute pyelonephritis; Triage; Intervention; In-hospital mortality; quick Sequential Organ Failure Assessment; National Early Warning Score 2; Early warning scores
Core Tip	Acute pyelonephritis (APN) is common in urology, but existing studies on early warning scores often mix heterogeneous sepsis cohorts or emphasize stone-related or emphysematous pyelonephritis. Our prospective study is the first to focus exclusively on non-obstructive, non-emphysematous APN, a group frequently overlooked yet clinically challenging. We demonstrate that the National Early Warning Score 2 score reliably identifies patients who require intensive care unit care or urgent intervention, while the quick Sequential Organ Failure Assessment score more accurately predicts mortality. Used together, they provide a complementary dual-score framework for bedside triage and prognostication. This simple approach offers urologists and nephrologists a practical, objective tool to enhance decision-making and improve patient outcomes.
Citation	Jain PR, Aravind S, K PR, Shekar M, Palaniyandi V, Sekar H, Krishnamoorthy S. Dual-score framework: National Early Warning Score 2 and quick Sequential Organ Failure Assessment scores in acute pyelonephritis. World J Nephrol 2025; In press

Received	2025-09-15 07:29
Peer-Review Started	2025-09-15 07:29
First Decision by Editorial Office Director	2025-09-23 09:36
Return for Revision	2025-09-23 09:36
Revised	2025-10-02 22:31
Publication Fee Transferred
Second Decision by Editor	2025-12-16 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-16 11:47
Articles in Press	2025-12-16 11:47
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-6124 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com