Publication Name	World Journal of Gastroenterology
Manuscript ID	114172
Country	United Kingdom

Category	Biology
Manuscript Type	Editorial
Article Title	Systemic inflammatory markers in gastric ulcer: Leveraging routine blood tests
Manuscript Source	Invited Manuscript
All Author List	Jin-Wei Zhang
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China No. 82170406 National Natural Science Foundation of China No. 81970238
Corresponding Author	Jin-Wei Zhang, Institute of Biomedical and Clinical Sciences, Medical School, Faculty of Health and Life Sciences, University of Exeter, Hatherly Laboratories, Streatham Campus, Stocker Road, Exeter EX4 4PS, United Kingdom. j.zhang5@exeter.ac.uk
Key Words	Gastric ulcer; Peptic ulcer disease; Systemic inflammatory response index; Neutrophil-to-lymphocyte ratio; Inflammation; Biomarkers
Core Tip	This editorial provides a critical analysis and appraisal of Shen et al’s study, which links six complete blood count-derived inflammatory indices (systemic inflammation markers) with gastric ulcer (GU) and demonstrates that systemic inflammatory response index (SIRI) exhibits the highest predictive value (area under the curve = 0.868) among these indices. While these inexpensive and accessible markers particularly SIRI may serve as practical tools for GU risk stratification, the editorial introduces a refined clinical framework for their application in this context and emphasizes the essential need for confirmation in prospective multicenter studies that account for Helicobacter pylori and non-steroidal anti-inflammatory drug confounders.
Citation	Zhang JW. Systemic inflammatory markers in gastric ulcer: Leveraging routine blood tests. World J Gastroenterol 2025; In press

Received	2025-09-15 03:06
Peer-Review Started	2025-09-15 03:06
To Make the First Decision
Return for Revision	2025-11-04 09:39
Revised	2025-11-07 08:02
Second Decision	2025-11-17 02:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-17 23:30
Articles in Press	2025-11-17 23:30
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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