Publication Name	World Journal of Gastroenterology
Manuscript ID	114184
Country	India

Category	Gastroenterology & Hepatology
Manuscript Type	Editorial
Article Title	Peroxiredoxin 1, pyroptosis, and the emerging frontier in colorectal cancer therapy
Manuscript Source	Invited Manuscript
All Author List	Dharmendra Kumar Maurya
Funding Agency and Grant Number
Corresponding Author	Dharmendra Kumar Maurya, PhD, Radiation Biology & Health Sciences Division, Bhabha Atomic Research Centre, 3-82-S, A-Block, Modular Laboratory, Mumbai 400085, Maharashtra, India. dkmaurya@barc.gov.in
Key Words	Colorectal cancer; Peroxiredoxin 1; Pyroptosis; Damage-associated molecular pattern; Immunogenic cell death
Core Tip	Peroxiredoxin 1, long regarded as an intracellular antioxidant that protect tumors from oxidative stress, assumes a paradoxical role in colorectal cancer therapy. He et al reveal that extracellular peroxiredoxin 1 acts as a damage-associated molecular pattern, activating the NOD-, LRR- and pyrin domain-containing protein 3 inflammasome/caspase-1/gasdermin D pathway to trigger pyroptosis. This lytic, pro-inflammatory death suppresses colorectal cancer proliferation, invasion, and migration while amplifying interleukin-1β/interleukin-18-mediated immune surveillance. Using patient cohorts, recombinant protein assays, and xenograft models, the study rigorously validates this mechanism.
Citation	Maurya DK. Peroxiredoxin 1, pyroptosis, and the emerging frontier in colorectal cancer therapy. World J Gastroenterol 2025; In press

Received	2025-09-15 13:47
Peer-Review Started	2025-09-15 13:48
To Make the First Decision
Return for Revision	2025-10-13 09:30
Revised	2025-10-22 06:36
Second Decision	2025-11-21 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-21 09:58
Articles in Press	2025-11-21 09:58
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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