Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	114205
Country	Peru

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Gastroenteropancreatic neuroendocrine tumors in 2025: From molecular profiling to artificial intelligence-driven therapy
Manuscript Source	Invited Manuscript
All Author List	Marcio J Concepción-Zavaleta, Jenyfer M Fuentes-Mendoza, José Paz-Ibarra, Luis A Concepción-Urteaga, Jeny Justina Mendoza-Godoy, Jhean G Gonzáles-Yovera, Juan Eduardo Quiroz-Aldave, Frederick Massucco-Revoredo, Augusto Aldave-Herrera and Regina Aquino-Salverredy
Funding Agency and Grant Number
Corresponding Author	Marcio J Concepción-Zavaleta, Grupo de Investigación en Neurociencias, Metabolismo, Efectividad Clínica y Salud Pública, Universidad Científica del Sur, 19 Panamericana Sur Km, Villa El Salvador, Lima 15072, Peru. mconcepcion@cientifica.edu.pe
Key Words	Gastroenteropancreatic neuroendocrine tumors; Precision medicine; Molecular profiling; Artificial intelligence; Theranostic imaging; Liquid biopsy biomarkers; Targeted therapies
Core Tip	Gastroenteropancreatic neuroendocrine tumors exhibit marked biological and clinical heterogeneity that extends beyond traditional histological classification. While molecular features distinguishing well-differentiated neuroendocrine tumors from poorly differentiated carcinomas provide a critical biological framework, they represent only one dimension of disease complexity. This review highlights how the integration of molecular profiling, artificial intelligence–based analytics, radiomics, liquid biopsy biomarkers (including NETest 2.0), and theranostic imaging enables a more comprehensive and dynamic approach to diagnosis, risk stratification, and therapeutic decision-making. An integrative precision medicine model is proposed to address tumor heterogeneity and support individualized, data-driven management strategies across the full spectrum of gastroenteropancreatic neuroendocrine tumors.
Citation	Concepción-Zavaleta MJ, Fuentes-Mendoza JM, Paz-Ibarra J, Concepción-Urteaga LA, Mendoza-Godoy JJ, Gonzáles-Yovera JG, Quiroz-Aldave JE, Massucco-Revoredo F, Aldave-Herrera A, Aquino-Salverredy R. Gastroenteropancreatic neuroendocrine tumors in 2025: From molecular profiling to artificial intelligence-driven therapy. World J Gastrointest Oncol 2025; In press

Received	2025-09-15 04:01
Peer-Review Started	2025-09-15 04:32
First Decision by Editorial Office Director	2025-10-13 09:30
Return for Revision	2025-10-15 10:27
Revised	2025-11-10 12:02
Publication Fee Transferred
Second Decision by Editor	2025-12-23 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-23 06:07
Articles in Press	2025-12-23 06:07
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Copyright	© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
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