Publication Name	World Journal of Hepatology
Manuscript ID	114206
Country	Italy

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Fatigue and circadian rhythm in non-cirrhotic primary biliary cholangitis: An exploratory comparison with primary sclerosing cholangitis and healthy controls
Manuscript Source	Invited Manuscript
All Author List	Armando Curto, Michele Tanturli, Rocco Gabriele Iamello, Pietro Rossi, Giulia Mengozzi, Leonardo Dei, Tommaso Mello, Tommaso Innocenti, Gabriele Dragoni, Andrea Galli and Erica Nicola Lynch
Funding Agency and Grant Number
Corresponding Author	Erica Nicola Lynch, Consultant, MD, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, Gastroenterology Research Unit, University of Florence, Largo Brambilla 3, Florence 50134, Tuscany, Italy. ericanicola.lynch@unifi.it
Key Words	Chronotype; Daytime sleepiness; Cholestatic disorders; Mental; Muscular; Primary biliary cholangitis; Primary sclerosing cholangitis
Core Tip	In non-cirrhotic primary biliary cholangitis, fatigue burden is similar to healthy controls and primary sclerosing cholangitis, but its phenotype is predominantly muscular (approximately 69%), independent of sex, age-adjusted employment, or routine disease metrics; daytime sleepiness and sleep duration are low/normal, and chronotype clusters in the intermediate range, with age - not disease - driving greater morningness. Primary sclerosing cholangitis shows a similar (weaker) direction of effect. These findings support routine fatigue phenotyping and muscle-focused interventions over cholestasis-directed therapies, and argue for objective endpoints (e.g., 31phosphorus magnetic resonance spectroscopy, actigraphy) in future trials.
Citation	Curto A, Tanturli M, Iamello RG, Rossi P, Mengozzi G, Dei L, Mello T, Innocenti T, Dragoni G, Galli A, Lynch EN. Fatigue and circadian rhythm in non-cirrhotic primary biliary cholangitis: An exploratory comparison with primary sclerosing cholangitis and healthy controls. World J Hepatol 2025; In press

Received	2025-09-15 07:45
Peer-Review Started	2025-09-15 07:45
First Decision by Editorial Office Director	2025-09-25 08:30
Return for Revision	2025-09-25 08:30
Revised	2025-10-05 19:47
Publication Fee Transferred
Second Decision by Editor	2025-12-12 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-12 08:13
Articles in Press	2025-12-12 08:13
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-5182 (online)
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