| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Evaluation of a 3,5-diethoxycarbonyl-1,4-dihydrocollidine diet-induced mouse model in a comparative experimental study of portal hypertension
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jin-Bo Zhao, Zheng-Hao Wu, Jia-Yun Lin, Gu-Qing Luo, Chi-Hao Zhang, Guang-Bo Wu, Qiang Fan, Xiao-Liang Qi, Hai-Zhong Huo, Ji-Wei Yu, Hong-Jie Li, Lei Zheng and Meng Luo |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Postdoctoral Scientific Research Foundation of Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine |
No. 202401023 |
| Shanghai Municipal Commission of Health and Family Planning |
No. 20244Y0195 |
| Shanghai Municipal Commission of Health and Family Planning |
No. 20234Y0132 |
| National Natural Science Foundation of China |
No. 82100639 |
| National Natural Science Foundation of China |
No. 82200630 |
| National Natural Science Foundation of China |
No. 81970526 |
|
| Corresponding Author |
Meng Luo, Chief Physician, Professor, Department of General Surgery, Ninth People’s Hospital Affiliated to Shanghai Jiao Tong University, School of Medicine, Shanghai Jiao Tong University, No. 639 Manufacturing Bureau Road, Shanghai 200011, China. luosh9hospital@sina.com |
| Key Words |
3,5-diethoxycarbonyl-1,4-dihydrocollidine; Portal hypertension; Mouse model; Portal pressure; Ductular reaction |
| Core Tip |
This study validates the 0.1% 3,5-diethoxycarbonyl-1,4-dihydrocollidine diet mouse model for biliary-related portal hypertension (PHT). It matches bile duct ligation (BDL) and carbon tetrachloride (CCl4) models in PHT pathologies (e.g., elevated portal pressure, sinusoidal changes) but outperforms them with 100% 4-week survival (vs 35% BDL, 58.3%-66.6% CCl4), simpler feed-based use, and better recapitulation of PHT hallmarks, serving as a superior alternative. |
| Citation |
Zhao JB, Wu ZH, Lin JY, Luo GQ, Zhang CH, Wu GB, Fan Q, Qi XL, Huo HZ, Yu JW, Li HJ, Zheng L, Luo M. Evaluation of a 3,5-diethoxycarbonyl-1,4-dihydrocollidine diet-induced mouse model in a comparative experimental study of portal hypertension. World J Gastroenterol 2025; In press |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
