Publication Name	World Journal of Critical Care Medicine
Manuscript ID	114225
Country	Italy

Category	Biochemistry & Molecular Biology
Manuscript Type	Minireviews
Article Title	MicroRNAs in sepsis: Advances in diagnosis and prognostic monitoring
Manuscript Source	Invited Manuscript
All Author List	Valeria Fraioli, Marco Sanvitti and Federico Bilotta
Funding Agency and Grant Number
Corresponding Author	Federico Bilotta, MD, PhD, Professor, Department of Anesthesiology and Intensive Care, University of Tor Vergata, Via Cracovia 50, Rome 00133, Lazio, Italy. bilotta@tiscali.it
Key Words	Sepsis; Septic shock; Circulating microRNAs; Biomarkers; Diagnosis; Prognosis; Extracellular vesicles; Precision medicine
Core Tip	Circulating microRNAs (miRNAs) are emerging as stable and specific biomarkers for sepsis and septic shock diagnosis, prognosis, and therapeutic monitoring. Recent studies validate miRNA-451a (miR-451a), miR-9-5p, miR-193b-5p, miR-135a, miR-155, and miR-182 as superior to conventional markers, reflecting disease severity and immune status. Future diagnostic strategies may benefit from combination miRNA panels, which could enhance accuracy and support precision medicine in sepsis care. Large multicenter studies and methodological standardization remain essential to ensure reproducibility and enable their integration into clinical practice.
Citation	Fraioli V, Sanvitti M, Bilotta F. MicroRNAs in sepsis: Advances in diagnosis and prognostic monitoring. World J Crit Care Med 2025; In press

Received	2025-09-15 04:40
Peer-Review Started	2025-09-15 04:40
First Decision by Editorial Office Director	2025-09-25 08:38
Return for Revision	2025-09-25 08:38
Revised	2025-10-07 18:55
Publication Fee Transferred
Second Decision by Editor	2025-12-16 02:41
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-16 07:03
Articles in Press	2025-12-16 07:03
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2220-3141(online)
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