Publication Name	World Journal of Gastroenterology
Manuscript ID	114243
Country	Egypt

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Egypt’s metabolic dysfunction associated steatotic liver disease: Genetic and dietary nexus, shaping artificial intelligence driven healthier future
Manuscript Source	Invited Manuscript
All Author List	Mona Hegazy, Mona Fathy, Omar Ashoush, Samah Abdelshafy, Dalia Abdelfatah, Samar Saad, Sawsan Abd El-Moniem, Wesam Ibrahim, Osama Ashraf, Shereen Saleh, Tarek Ahmed, Ragab Adly, Ali Abdel-Wahab, Ahmed Ahmed, Shadia Hussein, Ahmed Othman and Ahmed Abdelghani
Funding Agency and Grant Number	Funding Agency Grant Number Cairo University
Corresponding Author	Mona Hegazy, MD, Professor, Department of Internal Medicine, Hepatology and Gastroenterology, Kasr Alainy School of Medicine, Cairo University, Kasr Alainy Street, Cairo 12556, Al Qahirah, Egypt. monahegazy@cu.edu.eg
Key Words	Metabolic-dysfunction associated steatotic liver disease; Egypt; Epidemiology; PNPLA3; Metabolic syndrome; Nutrition
Core Tip	Egypt faces the world’s highest reported metabolic dysfunction associated steatotic liver disease prevalence (67.7%), driven by synergistic metabolic, dietary, and genetic factors. Obesity (27.5 times the risk), insulin resistance, high intake of refined carbohydrates, and PNPLA3 variants (present in 48% of cases) create a perfect metabolic storm. Alarmingly, 22% of lean individuals are affected, challenging traditional risk paradigms. These findings necessitate the implementation of urgent nationwide screening programs, culturally adapted lifestyle interventions, and the integration of genetic risk assessment into preventive strategies to combat this growing public health crisis.
Citation	Hegazy M, Fathy M, Ashoush O, Abdelshafy S, Abdelfatah D, Saad S, Abd El-Moniem S, Ibrahim W, Ashraf O, Saleh S, Ahmed T, Adly R, Abdel-Wahab A, Ahmed A, Hussein S, Othman A, Abdelghani A. Egypt’s metabolic dysfunction associated steatotic liver disease: Genetic and dietary nexus, shaping artificial intelligence driven healthier future. World J Gastroenterol 2026; In press

Received	2025-09-16 06:18
Peer-Review Started	2025-09-16 06:18
First Decision by Editorial Office Director	2025-11-10 07:35
Return for Revision	2025-11-10 07:35
Revised	2025-11-21 17:06
Publication Fee Transferred
Second Decision by Editor	2026-01-08 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-08 08:14
Articles in Press	2026-01-08 08:14
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1007-9327 (print) and 2219-2840 (online)
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