Publication Name	World Journal of Diabetes
Manuscript ID	114251
Country	China

Category	Nutrition & Dietetics
Manuscript Type	Letter to the Editor
Article Title	Exosomal miR-375-3p as a mediator of pancreas-liver crosstalk in impaired hepatic glycogenesis
Manuscript Source	Unsolicited Manuscript
All Author List	Tian-Han Xu and Dong-Mei Wang
Funding Agency and Grant Number
Corresponding Author	Dong-Mei Wang, Academic Fellow, PhD, Professor, Department of Gastrointestinal Surgery, Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, The Third Affiliated Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University, 68 Gehu Middle Road, Changzhou 213000, Jiangsu Province, China. fautywang@163.com
Key Words	Type 2 diabetes mellitus; Hepatic glycogenesis; Pancreas-liver crosstalk; Exosome; miR-375-3p; Pancreatic β cells; Hepatocytes
Core Tip	Xu et al revealed that pancreatic β-cell-derived exosomal miR-375-3p inhibits Rbpj expression in hepatocytes, leading to the suppression of the AKT/GSK signaling pathway and impaired hepatic glycogenesis. Their study identified a novel exosome-mediated pancreas-liver communication axis in the progression of diabetes, underscoring the promising role of exosomal microRNAs as both diagnostic biomarkers and therapeutic targets.
Citation	Xu TH, Wang DM. Exosomal miR-375-3p as a mediator of pancreas-liver crosstalk in impaired hepatic glycogenesis. World J Diabetes 2025; In press

Received	2025-09-15 00:28
Peer-Review Started	2025-09-15 08:13
To Make the First Decision
Return for Revision	2025-10-13 07:27
Revised	2025-10-24 22:15
Second Decision	2025-11-19 02:35
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-11-19 06:09
Articles in Press	2025-11-19 06:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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