Publication Name	World Journal of Diabetes
Manuscript ID	114252
Country	China

Category	Medicine, General & Internal
Manuscript Type	Basic Study
Article Title	Electroacupuncture protects gastric Cajal cells by reducing macrophage pyroptosis in diabetic gastroparesis
Manuscript Source	Unsolicited Manuscript
All Author List	Ming-Wei Fan, Jin-Lan Tian, Shu-Hui Zhang, Zi-Jian Zhao, Xin-Ru Liu, Cheng-Xia Liu and Yan Chen
Funding Agency and Grant Number
Corresponding Author	Yan Chen, PhD, Department of Gastroenterology, Binzhou Medical University Hospital, No. 661 Yellow River Second Road, Bincheng District, Binzhou 256603, Shandong Province, China. chenyanfeihong0906@163.com
Key Words	Diabetic gastroparesis; Interstitial cells of Cajal; Pyroptosis; Macrophages; Electroacupuncture
Core Tip	For the first time we show that high-frequency electroacupuncture at Zusanli acupoint outperforms low-frequency stimulation in diabetic gastroparesis by simultaneously blocking the cyclic GMP-AMP synthase-stimulator of interferon genes pathway, halting M2-macrophage pyroptosis, curtailing interleukin-1β/interleukin-18 release and thereby rescuing the interstitial cells of Cajal network, offering an immediately translatable, non-drug strategy to restore gastric motility.
Citation	Fan MW, Tian JL, Liu CX, Zhang SH, Zhao ZJ, Liu XR, Chen Y. Electroacupuncture protects gastric Cajal cells by reducing macrophage pyroptosis in diabetic gastroparesis. World J Diabetes 2025; In press

Received	2025-09-15 00:32
Peer-Review Started	2025-09-17 00:26
First Decision by Editorial Office Director	2025-09-23 09:39
Return for Revision	2025-09-23 09:39
Revised	2025-10-11 17:53
Publication Fee Transferred
Second Decision by Editor	2025-12-02 06:01
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-16 06:13
Articles in Press	2025-12-16 06:13
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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