Publication Name	World Journal of Diabetes
Manuscript ID	114253
Country	China

Category	Endocrinology & Metabolism
Manuscript Type	Prospective Study
Article Title	Using the triglyceride-glucose index and derived indexes to forecast progression from pre-diabetes to diabetes: A 3-year follow-up study
Manuscript Source	Unsolicited Manuscript
All Author List	Bing Wang, Ming-Chuan Liu, Xu-Han Liu, Zhu Zhu, Ying-Shu Liu, Ting-Ting Zhang, Xin-Yu Li and Zheng-Nan Gao
Funding Agency and Grant Number	Funding Agency Grant Number National Science and Technology Support Program Project No. 2013BAI09B13 Natural Science Foundation of Liaoning Province No. 2021-BS-294 Dengfeng Project of Dalian Medical Discipline Priority No. 2022ZZ258 Dengfeng Project of Dalian Medical Discipline Priority No. 2023ZZ025 Dengfeng Project of Dalian Medical Discipline Priority No. 2024ZZ016 Dengfeng Project of Dalian Medical Discipline Priority No. 2024ZZ034
Corresponding Author	Zheng-Nan Gao, Professor, Department of Endocrinology and Metabolism, Central Hospital of Dalian University of Technology, No. 826 Xinan Road, Dalian 116033, Liaoning Province, China. gao2008@163.com
Key Words	Triglyceride-glucose index; Triglyceride-glucose-body mass index; Triglyceride-glucose-waist circumference index; Pre-diabetes; Diabetes; Prospective cohort study
Core Tip	Pre-diabetes is an abnormal state of glucose metabolism between normal glucose tolerance and diabetes. If early intervention is carried out for risk factors in a pre-diabetic population, the occurrence and development of diabetes can be prevented. The triglyceride-glucose (TyG) index is a new index calculated according to triglycerides and fasting plasma glucose test. The latest research suggests that the TyG index and its derivative indexes, such as the product of TyG index and body mass index and the product of TyG index and waist circumference are novel and surrogate markers for insulin resistance. We prospectively investigated the relationship between TyG index and derived indexes and incident type 2 diabetes using a large sample, community-based cohort, aim at to find a simple indicator predicting the progression of a pre-diabetic population to diabetes, to allow relevant early-stage intervention in a pre-diabetic population and so reduce diabetes incidence.
Citation	Wang B, Liu MC, Liu XH, Zhu Z, Liu YS, Zhang TT, Li XY, Gao ZN. Using the triglyceride-glucose index and derived indexes to forecast progression from pre-diabetes to diabetes: A 3-year follow-up study. World J Diabetes 2025; In press

Received	2025-09-23 08:49
Peer-Review Started	2025-09-24 00:27
First Decision by Editorial Office Director	2025-10-11 02:56
Return for Revision	2025-10-11 02:56
Revised	2025-10-25 03:52
Publication Fee Transferred	2025-10-28 13:24
Second Decision by Editor	2025-12-10 02:54
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-17 07:56
Articles in Press	2025-12-17 07:56
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	1948-9358 (online)
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