Publication Name	World Journal of Methodology
Manuscript ID	114269
Country	Morocco

Category	Immunology
Manuscript Type	Minireviews
Article Title	Interleukin-1 receptor antagonist autoantibodies in Still’s disease: Mechanistic insights and laboratory testing
Manuscript Source	Invited Manuscript
All Author List	Abdellatif Bouayad
Funding Agency and Grant Number
Corresponding Author	Abdellatif Bouayad, Associate Professor, MD, Department of Immunology, Mohammed First University, Faculty of Medicine and Pharmacy Oujda, 4867 Oujda l’Université, Oujda-Angad 4867, Oriental, Morocco. a.bouayad@ump.ac.ma
Key Words	Still’s disease; Interleukin-1 receptor antagonist autoantibodies; Pathogenesis; Enzyme-linked immunosorbent; Isoelectric focusing; Western blot; Interleukin-1β signaling reporter cell assays
Core Tip	Still’s disease is a rare, severe systemic inflammatory disorder characterized by elevated levels of neutralizing interleukin-1 receptor antagonist autoantibodies. Their induction is thought to result from a combination of host-related factors, such as human leukocyte antigen class II alleles, and interleukin-1 receptor antagonist intrinsic factors, including hyperphosphorylation. Despite frequent detection of these antibodies using immunoassays and functional cell-based assays, the lack of assay standardization limits their clinical utility. At present, their presence is best regarded as a marker of underlying immune dysregulation rather than a direct pathogenic driver.
Citation	Bouayad A. Interleukin-1 receptor antagonist autoantibodies in Still’s disease: Mechanistic insights and laboratory testing. World J Methodol 2026; In press

Received	2025-09-15 00:39
Peer-Review Started	2025-09-15 00:39
First Decision by Editorial Office Director	2025-10-11 05:39
Return for Revision	2025-10-11 05:39
Revised	2025-10-13 14:24
Publication Fee Transferred
Second Decision by Editor	2026-01-06 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-07 01:53
Articles in Press	2026-01-07 01:53
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2222-0682 (online)
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