Publication Name	Artificial Intelligence in Cancer
Manuscript ID	114273
Country	China

Category	Medical Informatics
Manuscript Type	Review
Article Title	Synergistic applications of artificial intelligence and organoid technology in gastric precancerous lesion research: Mechanisms, translation, and challenges
Manuscript Source	Invited Manuscript
All Author List	Chen-Heng Wu, Jun-Xin Qiu, Yue-Bo Jia, Yi Quan, Chang Liu and Jiang-Hong Ling
Funding Agency and Grant Number	Funding Agency Grant Number National TCM Advantageous Specialty Project of National Administration of Traditional Chinese Medicine State Medical Letter on Chinese Medicine [2024]90 Shuguang Hospital Siming Foundation Research Special Project SGKJ-202304
Corresponding Author	Jiang-Hong Ling, Department of Gastroenterology, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, No. 528 Zhangheng Road, Shanghai 201203, China. ljh18817424778@163.com
Key Words	Gastric precancerous lesions; Artificial intelligence; Organoids; Integrative research; Precision medicine
Core Tip	We propose a transformative paradigm: Using artificial intelligence to decipher dynamic organoid phenotypes for forecasting gastric cancer (GC) risk. This review details how this synergy, which integrates high-throughput organoid screening with multimodal clinical data, unlocks the “black box” of disease progression. It empowers a shift from reactive diagnosis to proactive, mechanism-based precision prevention, ultimately pioneering a new era where GC is preemptively intercepted rather than treated.
Citation	Wu CH, Qiu JX, Jia YB, Quan Y, Liu C, Ling JH. Synergistic applications of artificial intelligence and organoid technology in gastric precancerous lesion research: Mechanisms, translation, and challenges. Artif Intell Cancer 2026; In press

Received	2025-09-15 07:53
Peer-Review Started	2025-09-15 07:53
First Decision by Editorial Office Director	2025-09-23 09:40
Return for Revision	2025-09-23 09:40
Revised	2025-10-06 21:34
Publication Fee Transferred
Second Decision by Editor	2026-01-12 02:39
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2026-01-12 04:06
Articles in Press	2026-01-12 04:06
Edit the Manuscript by Language Editor
Typeset the Manuscript

ISSN	2644-3228 (online)
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