Publication Name	World Journal of Hepatology
Manuscript ID	114291
Country	China

Category	Transplantation
Manuscript Type	Case Report
Article Title	De novo schizophrenia after liver transplantation: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Ji-Wei Qin, Jian-Cheng Wu, Hao Zheng, Can Qi, Ze-Bin Zhu, Xue-Feng Li, Ning Wang, Xiao-Dong Yuan, Zhi-Jun Xu, Wei Wu, Shu-Geng Zhang and Björn Nashan
Funding Agency and Grant Number	Funding Agency Grant Number Anhui Provincial Outstanding Youth Research Foundation for Higher Education Institutions of China 2022AH020077
Corresponding Author	Björn Nashan, FACS, FRCS (Gen Surg), MD, PhD, Professor, Department of Liver Transplantation, The First Affiliated Hospital of USTC, Hezeji Street, Shushan District, Hefei City, Hefei 230000, Anhui Province, China. bjoern.nashan@gmail.com
Key Words	De novo schizophrenia; Post-transplant psychosis; Calcineurin inhibitor neurotoxicity; Tacrolimus; Late-onset schizophrenia; Liver transplantation; Case report
Core Tip	We present the inaugural instance of new-onset schizophrenia occurring within one year post-liver transplantation in a 63-year-old female patient. The diagnosis was determined using structured interviews, sequential Positive and Negative Syndrome Scale scores, and thorough exclusion of metabolic, viral, and toxic variables. Following the commencement of antipsychotic treatment alongside low-dose tacrolimus and mycofenolate mofetil immunosuppression, the patient showed rapid improvement of symptoms, indicating calcineurin-inhibitor neurotoxicity as a direct catalyst; and surgical stress and anesthesia likely exacerbated individual vulnerability. This instance highlights the necessity for proactive neuropsychiatric monitoring and tailored immunosuppression in liver transplant recipients.
Citation	Qin JW, Wu JC, Zheng H, Qi C, Zhu ZB, Li XF, Wang N, Yuan XD, Xu ZJ, Wu W, Zhang SG, Nashan B. De novo schizophrenia after liver transplantation: A case report. World J Hepatol 2025; In press

Received	2025-09-18 02:56
Peer-Review Started	2025-09-18 02:59
First Decision by Editorial Office Director	2025-09-30 08:07
Return for Revision	2025-09-30 08:07
Revised	2025-11-02 16:55
Publication Fee Transferred	2025-11-08 08:49
Second Decision by Editor	2025-12-09 02:44
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director	2025-12-09 10:12
Articles in Press	2025-12-09 10:12
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Typeset the Manuscript

ISSN	1948-5182 (online)
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